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PMID: 110774 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Deoxyribonucleic acid sequence common to staphylococcal and streptococcal plasmids which specify erythromycin resistance.

Journal of bacteriology ·Vol. 138 ·No. 3 ·1979-06-00 ·Pages 990-8

Weisblum B, Holder SB, Halling SM

Abstract

Plasmids from erythromycin-resistant Staphylococcus aureus, Streptococcus sanguis, and Streptococcus faecalis show deoxyribonucleic acid sequence homology. The homologous sequences can be localized to specific restriction endonuclease fragments, which in the case of S. aureus plasmid pI258 involves a single fragment from either EcoRI or HindIII digest known to contain the erythromycin resistance determinant. Complementary ribonucleic acid probes prepared from S. aureus plasmid pI258 and S. sanguis plasmid pAM77 also hybridize to specific fragments in restriction endonuclease digests of deoxyribonucleic acid from erythromycin-resistant Streptococcus progenes and Streptococcus pneumoniae. These studies suggest a common origin for a class of erythromycin resistance determinants in unrelated strains of pathogenic bacteria for which exchange of genetic material has not been demonstrated.

MeSH Terms
Bacillus subtilis/analysis,drug effects Base Sequence DNA, Bacterial/analysis DNA, Circular/analysis Drug Resistance, Microbial Erythromycin/pharmacology Nucleic Acid Conformation R Factors Species Specificity Staphylococcus aureus/analysis,drug effects Streptococcus/analysis,drug effects
Chemicals
DNA, Bacterial DNA, Circular Erythromycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Weisblum B
Holder S B
Halling S M
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31 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.138.3.990-998.1979
Published
1979-06-00
Pages
990-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC218132
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.138.3.990-998.1979 PMC Full Text View journal details
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