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PMID: 11080252 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria.

The Journal of physiology ·Vol. 529 Pt 1 ·2000-11-15 ·Pages 69-81

Hajnóczky G, Csordás G, Madesh M, Pacher P

Abstract

Growing evidence suggests that propagation of cytosolic [Ca2+] ([Ca2+]c) spikes and oscillations to the mitochondria is important for the control of fundamental cellular functions. Delivery of [Ca2+]c spikes to the mitochondria may utilize activation of the mitochondrial Ca2+ uptake sites by the large local [Ca2+]c rise occurring in the vicinity of activated sarco-endoplasmic reticulum (SR/ER) Ca2+ release channels. Although direct measurement of the local [Ca2+]c sensed by the mitochondria has been difficult, recent studies shed some light onto the molecular mechanism of local Ca2+ communication between SR/ER and mitochondria. Subdomains of the SR/ER are in close contact with mitochondria and display a concentration of Ca2+ release sites, providing the conditions for an effective delivery of released Ca2+ to the mitochondrial targets. Furthermore, many functional properties of the signalling between SR/ER Ca2+ release sites and mitochondrial Ca2+ uptake sites, including transient microdomains of high [Ca2+], saturation of mitochondrial Ca2+ uptake sites by released Ca2+, connection of multiple release sites to each uptake site and quantal transmission, are analogous to the features of the coupling between neurotransmitter release sites and postsynaptic receptors in synaptic transmission. As such, Ca2+ signal transmission between SR/ER and mitochondria may utilize discrete communication sites and a closely related functional architecture to that used for synaptic signal propagation between cells.

MeSH Terms
Animals Calcium Signaling/physiology Humans Mitochondria/physiology Sarcoplasmic Reticulum/physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hajnóczky G
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. [email protected]
Csordás G
Madesh M
Pacher P
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1111/j.1469-7793.2000.00069.x
Email
[email protected]
Published
2000-11-15
Pages
69-81
Language
English
Region
England
NLM ID
0266262
PMCID
PMC2270182
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1469-7793.2000.00069.x PMC Full Text View journal details
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