What does 'chromatin remodeling' mean?

Trends in biochemical sciences ·Vol. 25 ·No. 11 ·2000-11-00 ·Pages 548-55

Aalfs JD, Kingston RE

Abstract

The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro.

MeSH Terms

Adenosine Triphosphatases/genetics,metabolism Adenosine Triphosphate/metabolism Animals Chromatin/chemistry,genetics,metabolism DNA-Binding Proteins Deoxyribonucleases, Type II Site-Specific/genetics,metabolism Drosophila Proteins Fungal Proteins/genetics,metabolism HSP70 Heat-Shock Proteins/genetics,metabolism Histones/genetics,metabolism Humans Promoter Regions, Genetic RNA-Binding Proteins Ribonucleoprotein, U1 Small Nuclear/genetics,metabolism Saccharomyces cerevisiae Proteins Transcription Factors/genetics,metabolism Yeasts/genetics

Chemicals

Chromatin DNA-Binding Proteins Drosophila Proteins Fungal Proteins HSP70 Heat-Shock Proteins Histones ISWI protein RNA-Binding Proteins Ribonucleoprotein, U1 Small Nuclear SWI4 protein, S cerevisiae Saccharomyces cerevisiae Proteins Transcription Factors snf protein, Drosophila Adenosine Triphosphate SCEI protein, S cerevisiae Deoxyribonucleases, Type II Site-Specific Adenosine Triphosphatases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Aalfs J D

Dept of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Kingston R E

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/s0968-0004(00)01689-3

Published

2000-11-00

Pages

548-55

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/s0968-0004(00)01689-3 View journal details

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What does 'chromatin remodeling' mean?

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