The DNA damage response: putting checkpoints in perspective.

Nature ·Vol. 408 ·No. 6811 ·2000-11-23 ·Pages 433-9

Zhou BB, Elledge SJ

Abstract

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

MeSH Terms

Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle/genetics Cell Cycle Proteins Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA Repair DNA-Binding Proteins Forecasting Humans Protein Kinases/physiology Protein Serine-Threonine Kinases/physiology Signal Transduction Tumor Suppressor Proteins

Chemicals

Cell Cycle Proteins DNA-Binding Proteins Tumor Suppressor Proteins Protein Kinases Checkpoint Kinase 2 ATM protein, human ATR protein, human Ataxia Telangiectasia Mutated Proteins CHEK2 protein, human Checkpoint Kinase 1 Protein Serine-Threonine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zhou B B

Department of Oncology Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.

Elledge S J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/35044005

Published

2000-11-23

Pages

433-9

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/35044005 View journal details

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