Abstract
In this 13-year study, 51 patients were admitted with the primary diagnosis of "smoke poisoning" "carbon monoxide (CO) poisoning" or "respiratory burns." Forty patients (78%) had diagnosis of smoke poisoning with minor or no skin burns. The study indicated that clinical diagnosis of CO poisoning cannot be made reliably without carboxyhemoglobin (COHg) determination and that smoke poisoning patients often had CO poisoning. Seventeen of 19 smoke poisoning patients (89%) had CO poisoning above COHb levels of 15% saturation. Carbon monoxide was successfully removed from the blood by improving alveolar ventilation and oxygen concentration. However, there were 2 smoke poisoning deaths as the result of gaseous chemical injury. There was a correlation coefficient of 0.87 between initial COHg levels and patients' hospital days primarily determined by patients' pulmonary complications. Since CO is non-irritating, COHb levels may be used as an additional indicator of suspected pulmonary injury by noxious combustion gases.
MeSH Terms
Animals
Asphyxia/blood,etiology,mortality
Burns, Inhalation/diagnosis,mortality
Carbon Monoxide Poisoning/blood,diagnosis,mortality
Carboxyhemoglobin/analysis
Diagnosis, Differential
Dogs
Fires
Follow-Up Studies
Gas Poisoning/blood,diagnosis,mortality
Humans
Kerosene
Length of Stay
Neurologic Manifestations
Smoke
Wood
Chemicals
Kerosene
Smoke
Carboxyhemoglobin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zikria B A
Budd D C
Floch F
Ferrer J M
References (13)
13 references, click to expand
-
MAXIMAL DIFFUSING CAPACITY OF THE LUNG FOR CARBON MONOXIDE.
J Clin Invest. 1965 Mar;44:349-55
PMID: 14271295
-
Burn therapy. II. The revelation of respiratory tract damage as a principal killer of the burned patient.
Ann Surg. 1962 Jan;155:1-19
PMID: 14486219
-
The Effects of Inhaled Heat on the Air Passages and Lungs: An Experimental Investigation.
Am J Pathol. 1945 Mar;21(2):311-31
PMID: 19970813
-
CLINICAL EXPERIENCE AND IMPLICATIONS OF HYPERBARIC OXYGENATION. CARBON MONOXIDE POISONING.
Ann N Y Acad Sci. 1965 Jan 21;117:684-7
PMID: 14252017
-
Treatment of coal-gas poisoning with oxygen at 2 atmospheres pressure.
Lancet. 1962 Apr 21;1(7234):816-9
PMID: 13914223
-
The reaction of formaldehyde with polynucleotides.
J Biol Chem. 1961 Oct;236:2738-45
PMID: 13905167
-
Effect of possible smog irritants on human subjects.
J Am Med Assoc. 1957 Dec 14;165(15):1908-13
PMID: 13480837
-
Effect of high oxygen tensions on diffusing capacity for CO and Krogh's K.
J Appl Physiol. 1967 Jul;23(1):11-7
PMID: 6028153
-
The production of carbon monoxide from hemoglobin in vivo.
J Clin Invest. 1967 Mar;46(3):346-56
PMID: 6024892
-
Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man.
J Clin Invest. 1965 Nov;44(11):1899-910
PMID: 5845666
-
Smoke and carbon monoxide poisoning in fire victims.
J Trauma. 1972 Aug;12(8):641-5
PMID: 5055192
-
The chemical factors contributing to pulmonary damage in "smoke poisoning".
Surgery. 1972 May;71(5):704-9
PMID: 5026960
-
Respiratory tract damage in burns: pathophysiology and therapy.
Ann N Y Acad Sci. 1968 Aug 14;150(3):618-26
PMID: 4882684