Why Helicobacter pylori has Lewis antigens.

Trends in microbiology ·Vol. 8 ·No. 12 ·2000-12-00 ·Pages 565-70

Appelmelk BJ, Monteiro MA, Martin SL, Moran AP, Vandenbroucke-Grauls CM

Abstract

In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

MeSH Terms

Bacterial Adhesion/physiology Carbohydrate Sequence Helicobacter Infections/microbiology Helicobacter pylori/immunology,pathogenicity,physiology Humans Lewis Blood Group Antigens/chemistry,immunology,physiology Molecular Mimicry Molecular Sequence Data O Antigens/chemistry,immunology,physiology Virulence

Chemicals

Lewis Blood Group Antigens O Antigens

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Appelmelk B J

Dept of Medical Microbiology, Vrije Universiteit, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. [email protected]

Monteiro M A

Martin S L

Moran A P

Vandenbroucke-Grauls C M

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/s0966-842x(00)01875-8

[email protected]

Published

2000-12-00

Pages

565-70

Language

English

Region

England

NLM ID

9310916

Subset

External Links

PubMed source DOI: 10.1016/s0966-842x(00)01875-8 View journal details

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