Home LiteratureArticle Details
PMID: 11118151 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Functional requirement for class I MHC in CNS development and plasticity.

Science (New York, N.Y.) ·Vol. 290 ·No. 5499 ·2000-12-15 ·Pages 2155-9

Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ

Abstract

Class I major histocompatibility complex (class I MHC) molecules, known to be important for immune responses to antigen, are expressed also by neurons that undergo activity-dependent, long-term structural and synaptic modifications. Here, we show that in mice genetically deficient for cell surface class I MHC or for a class I MHC receptor component, CD3zeta, refinement of connections between retina and central targets during development is incomplete. In the hippocampus of adult mutants, N-methyl-D-aspartate receptor-dependent long-term potentiation (LTP) is enhanced, and long-term depression (LTD) is absent. Specific class I MHC messenger RNAs are expressed by distinct mosaics of neurons, reflecting a potential for diverse neuronal functions. These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS).

MeSH Terms
Animals Brain/growth & development,physiology CD3 Complex/genetics,physiology Excitatory Postsynaptic Potentials Gene Expression Profiling Genes, MHC Class I Geniculate Bodies/physiology Hippocampus/growth & development,physiology Histocompatibility Antigens Class I/genetics,physiology In Situ Hybridization Long-Term Potentiation Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Neural Pathways Neuronal Plasticity Neurons/physiology Receptors, GABA-A/metabolism Receptors, N-Methyl-D-Aspartate/metabolism Retina/growth & development,physiology Retinal Ganglion Cells/physiology Signal Transduction Synapses/physiology Synaptic Transmission Visual Pathways
Chemicals
CD3 Complex CD3 antigen, zeta chain Histocompatibility Antigens Class I Receptors, GABA-A Receptors, N-Methyl-D-Aspartate
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Huh G S
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. [email protected]
Boulanger L M
Du H
Riquelme P A
Brotz T M
Shatz C J
References (39)
39 references, click to expand
  1. Prenatal and postnatal development of retinogeniculate and retinocollicular projections in the mouse.
    J Comp Neurol. 1984 Dec 20;230(4):552-75 PMID: 6520251
  2. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system.
    Cell. 1991 Jan 11;64(1):189-200 PMID: 1986864
  3. Development of the mammalian retinogeniculate pathway: target finding, transient synapses and binocular segregation.
    J Exp Biol. 1990 Oct;153:85-104 PMID: 2280230
  4. RAG-1-deficient mice have no mature B and T lymphocytes.
    Cell. 1992 Mar 6;68(5):869-77 PMID: 1547488
  5. Synapses formed by identified retinogeniculate axons during the segregation of eye input.
    J Neurosci. 1992 May;12(5):1847-58 PMID: 1578274
  6. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.
    Science. 1992 Dec 18;258(5090):1903-10 PMID: 1361685
  7. A synaptic model of memory: long-term potentiation in the hippocampus.
    Nature. 1993 Jan 7;361(6407):31-9 PMID: 8421494
  8. Developmental mechanisms that generate precise patterns of neuronal connectivity.
    Cell. 1993 Jan;72 Suppl:77-98 PMID: 8428376
  9. T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
    Science. 1993 Aug 13;261(5123):918-21 PMID: 7688481
  10. Assembly and intracellular transport of MHC class I molecules.
    Annu Rev Cell Biol. 1993;9:207-35 PMID: 8280460
  11. Antigen presentation by major histocompatibility complex class I-B molecules.
    Annu Rev Immunol. 1994;12:839-80 PMID: 8011299
  12. Mechanism for a sliding synaptic modification threshold.
    Neuron. 1995 Jul;15(1):1-4 PMID: 7619513
  13. Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps.
    Cell. 1995 Aug 11;82(3):345-8 PMID: 7634322
  14. Synaptic plasticity: A molecular mechanism for metaplasticity.
    Curr Biol. 1995 Dec 1;5(12):1334-8 PMID: 8749377
  15. Synaptic activity and the construction of cortical circuits.
    Science. 1996 Nov 15;274(5290):1133-8 PMID: 8895456
  16. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha.
    J Exp Med. 1997 Jan 20;185(2):305-16 PMID: 9016879
  17. Competition in retinogeniculate patterning driven by spontaneous activity.
    Science. 1998 Mar 27;279(5359):2108-12 PMID: 9516112
  18. The basis for self-tolerance of natural killer cells in beta2-microglobulin- and TAP-1- mice.
    J Immunol. 1997 Dec 1;159(11):5219-25 PMID: 9548460
  19. Regulation of class I MHC gene expression in the developing and mature CNS by neural activity.
    Neuron. 1998 Sep;21(3):505-20 PMID: 9768838
  20. Thymocyte selection: not by TCR alone.
    Immunol Rev. 1998 Oct;165:209-29 PMID: 9850863
  21. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.
    Nature. 1998 Dec 3;396(6710):433-9 PMID: 9853749
  22. Topographic guidance labels in a sensory projection to the forebrain.
    Neuron. 1998 Dec;21(6):1303-13 PMID: 9883724
  23. Neuronal activity during development: permissive or instructive?
    Curr Opin Neurobiol. 1999 Feb;9(1):88-93 PMID: 10072369
  24. Retinal waves and visual system development.
    Annu Rev Neurosci. 1999;22:29-47 PMID: 10202531
  25. The mouse major histocompatibility complex: some assembly required.
    Immunol Rev. 1999 Feb;167:211-21 PMID: 10319263
  26. Selection of the T cell repertoire.
    Annu Rev Immunol. 1999;17:829-74 PMID: 10358775
  27. T cell antigen-receptor signal transduction.
    Curr Opin Immunol. 1999 Jun;11(3):242-8 PMID: 10375551
  28. Long-term potentiation--a decade of progress?
    Science. 1999 Sep 17;285(5435):1870-4 PMID: 10489359
  29. Synaptic plasticity at thalamocortical synapses in developing rat somatosensory cortex: LTP, LTD, and silent synapses.
    J Neurobiol. 1999 Oct;41(1):92-101 PMID: 10504196
  30. Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver.
    Cell. 1985 Jun;41(2):469-78 PMID: 3838699
  31. Impulse activity and the patterning of connections during CNS development.
    Neuron. 1990 Dec;5(6):745-56 PMID: 2148486
  32. The structure of the dorsal lateral geniculate nucleus in the mouse. A Golgi and electron microscopic study.
    J Comp Neurol. 1973 Aug;150(3):303-32 PMID: 4124620
  33. Aspects of the synaptic organization of intrinsic neurons in the dorsal lateral geniculate nucleus. An ultrastructural study of the normal and of the experimentally deafferented nucleus in the rat.
    J Neurocytol. 1974 Dec;3(6):677-710 PMID: 4461771
  34. Prenatal development of retinal ganglion cell axons: segregation into eye-specific layers within the cat's lateral geniculate nucleus.
    J Neurosci. 1986 Jan;6(1):234-51 PMID: 3944621
  35. Impaired hippocampal plasticity in experimental chronic hydrocephalus.
    Brain Inj. 1988 Jan-Mar;2(1):19-30 PMID: 2844349
  36. Prenatal tetrodotoxin infusion blocks segregation of retinogeniculate afferents.
    Science. 1988 Oct 7;242(4875):87-9 PMID: 3175636
  37. Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin.
    Nature. 1988 Dec 1;336(6198):468-71 PMID: 2461517
  38. Synaptogenesis in the dorsal lateral geniculate nucleus of the rat.
    Anat Embryol (Berl). 1989;180(3):243-57 PMID: 2596705
  39. Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.
    Nature. 1990 Apr 19;344(6268):742-6 PMID: 2139497
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.290.5499.2155
Email
[email protected]
Published
2000-12-15
Pages
2155-9
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2175035
Subset
IM
Grants
NEI NIH HHS · F32 EY007016-02 · United States
NEI NIH HHS · F32 EY007016-03 · United States
NIMH NIH HHS · MH48108 · United States
NEI NIH HHS · EY06912 · United States
NEI NIH HHS · F32 EY007016 · United States
NEI NIH HHS · 1F32EY07016 · United States
Corrections
CommentIn
PMID: 11187818
CommentIn
PMID: 24439553
External Links
PubMed source DOI: 10.1126/science.290.5499.2155 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2