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PMID: 11124996 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 20 ·No. 24 ·2000-12-15 ·Pages 9187-94

Cirelli C, Tononi G

Abstract

Behavioral studies indicate that the ability to acquire long-term memories is severely impaired during sleep. It is unclear, however, why the highly synchronous discharge of neurons during sleep should not be followed by the induction of enduring plastic changes. Here we show that the expression of phosphorylated CRE-binding protein, Arc, and BDNF, three genes whose induction is often associated with synaptic plasticity, is high during waking and low during sleep. We also show that the induction of these genes during waking depends on the activity of the noradrenergic system, which is high in waking and low in sleep. These molecular results complement behavioral evidence and provide a mechanism for the impairment of long-term memory acquisition during sleep.

MeSH Terms
Animals Brain-Derived Neurotrophic Factor/genetics,metabolism Cerebral Cortex/drug effects,metabolism Circadian Rhythm Cyclic AMP Response Element-Binding Protein/metabolism Cytoskeletal Proteins/genetics,metabolism Electroencephalography Electromyography Gene Expression Regulation/genetics Hippocampus/drug effects,metabolism Locus Coeruleus/drug effects,metabolism Long-Term Potentiation/physiology Male Memory/physiology Nerve Tissue Proteins/genetics,metabolism Neuronal Plasticity/genetics,physiology Phosphorylation RNA, Messenger/metabolism Rats Rats, Inbred WKY Receptors, Adrenergic/metabolism Serotonin Uptake Inhibitors/pharmacology Sleep/genetics,physiology Sleep Deprivation/metabolism Wakefulness/genetics,physiology
Chemicals
Brain-Derived Neurotrophic Factor Cyclic AMP Response Element-Binding Protein Cytoskeletal Proteins Nerve Tissue Proteins RNA, Messenger Receptors, Adrenergic Serotonin Uptake Inhibitors activity regulated cytoskeletal-associated protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cirelli C
The Neurosciences Institute, San Diego, California 92121, USA. [email protected]
Tononi G
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Email
[email protected]
Published
2000-12-15
Pages
9187-94
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6773024
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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