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PMID: 11128001 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Nitrite-dependent nitric oxide production pathway: implications for involvement of active nitrogen species in photoinhibition in vivo.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 355 ·No. 1402 ·2000-10-29 ·Pages 1477-88

Yamasaki H

Abstract

Air pollution studies have shown that nitric oxide (NO), a gaseous free radical, is a potent photosynthetic inhibitor that reduces CO2 uptake activity in leaves. It is now recognized that NO is not only an air pollutant but also an endogenously produced metabolite, which may play a role in regulating plant cell functions. Although many studies have suggested the presence of mammalian-type NO synthase (NOS) in plants, the source of NO is still not clear. There has been a number of studies indicating that plant cells possess a nitrite-dependent NO production pathway which can be distinguished from the NOS-mediated reaction. Nitrate reductase (NR) has been recently found to be capable of producing NO through one-electron reduction of nitrite using NAD(P)H as an electron donor. This review focuses on current understanding of the mechanism for the nitrite-dependent NO production in plants. Impacts of NO produced by NR on photosynthesis are discussed in association with photo-oxidative stress in leaves.

MeSH Terms
Animals Humans Nitrate Reductase Nitrate Reductases/metabolism Nitrates/metabolism Nitric Oxide/metabolism Nitrites/metabolism Photosynthesis/physiology Plant Physiological Phenomena
Chemicals
Nitrates Nitrites peroxynitric acid Nitric Oxide Nitrate Reductases Nitrate Reductase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Yamasaki H
Laboratory of Cell and Functional Biology, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, Japan. [email protected]
References (64)
64 references, click to expand
  1. Environmental effects on photosynthesis, nitrogen-use efficiency, and metabolite pools in leaves of sun and shade plants.
    Plant Physiol. 1987 Jul;84(3):796-802 PMID: 16665524
  2. THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.
    Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun;50:601-639 PMID: 15012221
  3. Detection of nitric oxide interaction with zinc finger proteins.
    Methods Enzymol. 1996;269:279-84 PMID: 8791656
  4. Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
    J Med Chem. 1992 Jan 24;35(2):267-73 PMID: 1732542
  5. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.
    Free Radic Biol Med. 1998 Sep;25(4-5):434-56 PMID: 9741580
  6. Phosphorylated nitrate reductase and 14-3-3 proteins. Site of interaction, effects of ions, and evidence for an amp-binding site on 14-3-3 proteins.
    Plant Physiol. 1998 Nov;118(3):1041-8 PMID: 9808749
  7. The Conversion of Nitrite to Nitrogen Oxide(s) by the Constitutive NAD(P)H-Nitrate Reductase Enzyme from Soybean.
    Plant Physiol. 1988 Oct;88(2):389-95 PMID: 16666314
  8. Blue light activates the plasma membrane H(+)-ATPase by phosphorylation of the C-terminus in stomatal guard cells.
    EMBO J. 1999 Oct 15;18(20):5548-58 PMID: 10523299
  9. Soybean Mutants Lacking Constitutive Nitrate Reductase Activity : II. Nitrogen Assimilation, Chlorate Resistance, and Inheritance.
    Plant Physiol. 1983 Jun;72(2):510-4 PMID: 16663033
  10. Protection against peroxynitrite.
    FEBS Lett. 1999 Feb 26;445(2-3):226-30 PMID: 10094462
  11. Nitric oxide as a signal in plants.
    Curr Opin Plant Biol. 1999 Oct;2(5):369-74 PMID: 10508751
  12. Kinetic analysis of reactivity of peroxynitrite with biomolecules.
    Methods Enzymol. 1996;269:354-66 PMID: 8791664
  13. Posttranslational Regulation of Nitrate Reductase in Higher Plants.
    Plant Physiol. 1994 Nov;106(3):817-821 PMID: 12232369
  14. Bleaching of the red anthocyanin induced by superoxide radical.
    Arch Biochem Biophys. 1996 Aug 1;332(1):183-6 PMID: 8806724
  15. Nitric Oxide and Nitrous Oxide Production by Soybean and Winged Bean during the in Vivo Nitrate Reductase Assay.
    Plant Physiol. 1986 Nov;82(3):718-23 PMID: 16665099
  16. Superoxide production during reduction of molecular oxygen by assimilatory nitrate reductase.
    Arch Biochem Biophys. 1996 Feb 15;326(2):227-32 PMID: 8611027
  17. Scavenging of peroxynitrite by a phenolic/peroxidase system prevents oxidative damage to DNA.
    FEBS Lett. 1998 Apr 10;426(1):24-8 PMID: 9598971
  18. Nonenzymatic nitric oxide production in humans.
    Nitric Oxide. 1998;2(1):1-7 PMID: 9706737
  19. Acetaldehyde Oxime, A Product Formed during the In Vivo Nitrate Reductase Assay of Soybean Leaves.
    Plant Physiol. 1984 Sep;76(1):118-24 PMID: 16663781
  20. Nitrite Transport in Chloroplast Inner Envelope Vesicles (I. Direct Measurement of Proton-Linked Transport).
    Plant Physiol. 1996 Nov;112(3):1375-1381 PMID: 12226452
  21. Nitrate Reductases from Wild-Type and nr(1)-Mutant Soybean (Glycine max [L.] Merr.) Leaves : I. Purification, Kinetics, and Physical Properties.
    Plant Physiol. 1985 May;78(1):80-4 PMID: 16664214
  22. Direct detection of radicals in intact soybean nodules: presence of nitric oxide-leghemoglobin complexes.
    Free Radic Biol Med. 1998 May;24(7-8):1242-9 PMID: 9626580
  23. Diffusion of free nitric oxide.
    Methods Enzymol. 1996;268:31-50 PMID: 8782571
  24. Nitric oxide functions as a signal in plant disease resistance.
    Nature. 1998 Aug 6;394(6693):585-8 PMID: 9707120
  25. Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123.
    Methods Enzymol. 1999;301:367-73 PMID: 9919585
  26. Reduction of nitrite to nitric oxide by enteric bacteria.
    Biochem Biophys Res Commun. 1988 Nov 30;157(1):106-8 PMID: 3058123
  27. Dark induction of zeaxanthin-dependent nonphotochemical fluorescence quenching mediated by ATP.
    Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1899-903 PMID: 1542689
  28. The reaction of peroxynitrite with zeaxanthin.
    Nitric Oxide. 1998;2(1):8-16 PMID: 9706738
  29. Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.
    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3377-82 PMID: 8622943
  30. Suppression of plant growth by nitrogen dioxide.
    Plant Physiol. 1966 Jan;41(1):132-5 PMID: 5904586
  31. Growth phase-dependent subcellular localization of nitric oxide synthase in maize cells.
    FEBS Lett. 1999 Feb 26;445(2-3):283-6 PMID: 10094473
  32. NITRATE REDUCTASE STRUCTURE, FUNCTION AND REGULATION: Bridging the Gap between Biochemistry and Physiology.
    Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun;50:277-303 PMID: 15012211
  33. EPR detection of phytophenoxyl radicals stabilized by zinc ions: evidence for the redox coupling of plant phenolics with ascorbate in the H2O2-peroxidase system.
    FEBS Lett. 1998 Feb 6;422(3):377-80 PMID: 9498820
  34. Nitrate regulation of metabolism and growth.
    Curr Opin Plant Biol. 1999 Jun;2(3):178-86 PMID: 10375569
  35. Nitric oxide inhibits the cytochrome oxidase but not the alternative oxidase of plant mitochondria.
    FEBS Lett. 1996 Dec 2;398(2-3):155-8 PMID: 8977097
  36. Nitrate: nutrient and signal for plant growth.
    Plant Cell. 1995 Jul;7(7):859-68 PMID: 7640524
  37. Nitric oxide radical scavenging of flavonoids.
    Methods Enzymol. 1999;301:490-503 PMID: 9919597
  38. Determination of nitric oxide using fluorescence spectroscopy.
    Methods Enzymol. 1996;268:105-20 PMID: 8782577
  39. Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide.
    Free Radic Biol Med. 1998 Sep;25(4-5):392-403 PMID: 9741578
  40. Inhibition of tobacco nitrite reductase activity by expression of antisense RNA.
    Plant J. 1992 Jul;2(4):559-69 PMID: 1285356
  41. Flavonoid-Peroxidase Reaction as a Detoxification Mechanism of Plant Cells against H2O2.
    Plant Physiol. 1997 Dec;115(4):1405-1412 PMID: 12223873
  42. Is nitric oxide toxic or protective?
    Trends Plant Sci. 1999 Aug;4(8):299-300 PMID: 10431217
  43. Soybean mutants lacking constitutive nitrate reductase activity : I. Selection and initial plant characterization.
    Plant Physiol. 1983 Jun;72(2):503-9 PMID: 16663032
  44. Carotenoids 3: in vivo function of carotenoids in higher plants.
    FASEB J. 1996 Mar;10(4):403-12 PMID: 8647339
  45. Role of active oxygen species and NO in plant defence responses.
    Curr Opin Plant Biol. 1999 Aug;2(4):287-94 PMID: 10459001
  46. Enzymology of nitric oxide synthases.
    Methods Mol Biol. 1998;100:1-32 PMID: 10906988
  47. Reaction of peroxynitrite and hydrogen peroxide to produce singlet molecular oxygen (1deltag).
    Methods Enzymol. 1996;269:395-400 PMID: 8791668
  48. Peroxynitrite modulates tyrosine phosphorylation and phosphoinositide signalling in human neuroblastoma SH-SY5Y cells: attenuated effects in human 1321N1 astrocytoma cells.
    Biochem J. 1998 Apr 15;331 ( Pt 2):599-606 PMID: 9531503
  49. Evolution of Nitrogen Oxide(s) during In Vivo Nitrate Reductase Assay of Soybean Leaves.
    Plant Physiol. 1981 Dec;68(6):1488-93 PMID: 16662132
  50. The basic chemistry of nitrogen monoxide and peroxynitrite.
    Free Radic Biol Med. 1998 Sep;25(4-5):385-91 PMID: 9741577
  51. An alternative pathway for nitric oxide production in plants: new features of an old enzyme.
    Trends Plant Sci. 1999 Apr;4(4):128-129 PMID: 10322545
  52. Simultaneous production of nitric oxide and peroxynitrite by plant nitrate reductase: in vitro evidence for the NR-dependent formation of active nitrogen species.
    FEBS Lett. 2000 Feb 18;468(1):89-92 PMID: 10683447
  53. Nitric oxide regulation of lipid oxidation reactions: formation and analysis of nitrogen-containing oxidized lipid derivatives.
    Methods Enzymol. 1996;269:385-94 PMID: 8791667
  54. Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins.
    FEBS Lett. 1998 May 8;427(2):263-6 PMID: 9607324
  55. Determination of NO with a Clark-type electrode.
    Methods Mol Biol. 1998;100:101-9 PMID: 10906998
  56. Effects of Growth Irradiance and Nitrogen Limitation on Photosynthetic Energy Conversion in Photosystem II.
    Plant Physiol. 1988 Nov;88(3):923-9 PMID: 16666405
  57. The mechanism of the control of carbon fixation by the pH in the chloroplast stroma. Studies with nitrite-mediated proton transfer across the envelope.
    Biochim Biophys Acta. 1978 Mar 13;501(3):488-98 PMID: 24470
  58. Presence of nitric oxide synthase activity in roots and nodules of Lupinus albus.
    FEBS Lett. 1996 Dec 2;398(2-3):159-64 PMID: 8977098
  59. Comparison between NO(x) Evolution Mechanisms of Wild-Type and nr(1) Mutant Soybean Leaves.
    Plant Physiol. 1990 May;93(1):26-32 PMID: 16667445
  60. Indications for the occurrence of nitric oxide synthases in fungi and plants and the involvement in photoconidiation of Neurospora crassa.
    Photochem Photobiol. 1996 Aug;64(2):393-8 PMID: 8760579
  61. Urinary nitrite: more than a marker of infection.
    Urology. 1997 Aug;50(2):189-91 PMID: 9255286
  62. Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin.
    Curr Biol. 1996 Sep 1;6(9):1104-13 PMID: 8805370
  63. Nitrate Reductase Activity in Soybeans (Glycine max [L.] Merr.): I. Effects of Light and Temperature.
    Plant Physiol. 1976 Dec;58(6):731-5 PMID: 16659755
  64. Regulation of nitrite reductase and its relationship to the regulation of nitrate reductase in cultured tobacco cells.
    Biochim Biophys Acta. 1971 Oct;252(1):69-82 PMID: 5141829
Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.2000.0708
Email
[email protected]
Published
2000-10-29
Pages
1477-88
Language
English
Region
England
NLM ID
7503623
PMCID
PMC1692879
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.2000.0708 PMC Full Text View journal details
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