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PMID: 11137030 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Wnt signaling: an embarrassment of receptors.

Current biology : CB ·Vol. 10 ·No. 24 ·2000-00-00 ·Pages R919-22

Bejsovec A

Abstract

Recent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal transduction machinery. Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co-receptors for Wnt ligands.

MeSH Terms

Animals Drosophila Proteins Frizzled Receptors Membrane Glycoproteins/metabolism Membrane Proteins/metabolism Mitogens/genetics,metabolism Models, Biological Morphogenesis/genetics Proteoglycans/metabolism Proto-Oncogene Proteins/genetics,metabolism Receptors, G-Protein-Coupled Receptors, LDL/genetics,metabolism Signal Transduction/physiology Wnt Proteins Zebrafish Proteins

Chemicals

Drosophila Proteins Frizzled Receptors Membrane Glycoproteins Membrane Proteins Mitogens Proteoglycans Proto-Oncogene Proteins Receptors, G-Protein-Coupled Receptors, LDL Wnt Proteins Zebrafish Proteins dally protein, Drosophila fz protein, Drosophila

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bejsovec A

Department of Biology, Duke University, B336 LSRC Box 91000, Durham, North Carolina 27708, USA. [email protected]

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(00)00852-6

[email protected]

Published

2000-00-00

Pages

R919-22

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(00)00852-6 View journal details

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