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PMID: 11156601 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Requirement for math5 in the development of retinal ganglion cells.

Genes & development ·Vol. 15 ·No. 1 ·2001-01-01 ·Pages 24-9

Wang SW, Kim BS, Ding K, Wang H, Sun D, Johnson RL, Klein WH, Gan L

Abstract

math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.

MeSH Terms
Animals Basic Helix-Loop-Helix Transcription Factors Cell Differentiation Choline O-Acetyltransferase/analysis DNA-Binding Proteins/genetics Drosophila/genetics Drosophila Proteins Helix-Loop-Helix Motifs Isoenzymes/analysis Membrane Proteins/analysis Mice Mice, Knockout Nerve Tissue Proteins/deficiency,genetics,physiology Protein Kinase C/analysis Protein Kinase C-alpha Qa-SNARE Proteins Retina/cytology,physiology Retinal Ganglion Cells/cytology,physiology Transcription Factor Brn-3 Transcription Factor Brn-3B Transcription Factors/deficiency,genetics,physiology
Chemicals
Atoh1 protein, mouse Atoh7 protein, mouse Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Drosophila Proteins Isoenzymes Membrane Proteins Nerve Tissue Proteins Qa-SNARE Proteins Transcription Factor Brn-3 Transcription Factor Brn-3B Transcription Factors ato protein, Drosophila Choline O-Acetyltransferase Prkca protein, mouse Protein Kinase C Protein Kinase C-alpha
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wang S W
Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Kim B S
Ding K
Wang H
Sun D
Johnson R L
Klein W H
Gan L
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.855301
Published
2001-01-01
Pages
24-9
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC312600
Subset
IM
Grants
NEI NIH HHS · R01 EY011930 · United States
NEI NIH HHS · R01EY11930 · United States
External Links
PubMed source DOI: 10.1101/gad.855301 PMC Full Text View journal details
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