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PMID: 1116872 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immune response to hepatitis B surface antigen.

Infection and immunity ·Vol. 11 ·No. 1 ·1975-01-00 ·Pages 137-41

Ibrahim AB, Vyas GN, Perkins HA

Abstract

A total of 69 persons were investigated for assessment of cell-mediated and humoral immunity to hepatitis B surface antigen (HBsAg). Three groups, each consisting of 20 normal persons, 20HBsAg carriers, and 20 convalescent hepatitis B patients, were studied for HBsAg, anti-HBs, and leukocyte migration inhibition with purified HBsAg. Sequential sampling if an additional group of nine acute hepatitis B patients defined the cellular and humoral immune response to HBsAg. The antigen was eliminated rapidly by mounting of cell-mediated immune response detectable for a limited period, followed by antibody response in relatively few patients moore than 3 months after clearance of circulating HBsAg.

MeSH Terms
Antibody Formation Cell Migration Inhibition Centrifugation, Density Gradient Countercurrent Distribution Hemagglutination Inhibition Tests Hepatitis B/immunology Hepatitis B Antibodies/analysis Hepatitis B Antigens/analysis Humans Immunity, Cellular Immunoelectrophoresis Leukocytes/immunology Radioimmunoassay
Chemicals
Hepatitis B Antibodies Hepatitis B Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ibrahim A B
Vyas G N
Perkins H A
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21 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.11.1.137-141.1975
Published
1975-01-00
Pages
137-41
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415036
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.11.1.137-141.1975 PMC Full Text View journal details
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