Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs.

The American journal of medicine ·Vol. 110 Suppl 3A ·2001-02-19 ·Pages 20S-7S

Hernández-Díaz S, García-Rodríguez LA

Abstract

The use of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with upper gastrointestinal bleeding and perforation (UGIB), acute liver injury, acute renal injury, heart failure, and adverse reproductive outcomes. This article summarizes the effects of various factors, such as NSAID dose, duration of treatment, patient age, and ulcer history, on the incidences of these adverse side effects. We used the UK General Practice Research Database to study further the principal safety concern related to NSAIDs, namely, UGIB.

MeSH Terms

Acute Disease Adult Aged Anti-Inflammatory Agents, Non-Steroidal/adverse effects Chemical and Drug Induced Liver Injury Databases, Factual Family Practice Female Gastrointestinal Hemorrhage/chemically induced,epidemiology Heart Failure/chemically induced,epidemiology Humans Incidence Kidney Diseases/chemically induced,epidemiology Liver Diseases/epidemiology Male Middle Aged Pharmacoepidemiology Pregnancy Reproduction/drug effects Risk Factors Safety United Kingdom/epidemiology

Chemicals

Anti-Inflammatory Agents, Non-Steroidal

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hernández-Díaz S

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

García-Rodríguez L A

Article Info

Journal

The American journal of medicine

Abbr.

Am J Med

ISSN

0002-9343

DOI

10.1016/s0002-9343(00)00682-3

Published

2001-02-19

Pages

20S-7S

Language

English

Region

United States

NLM ID

0267200

Subset

External Links

PubMed source DOI: 10.1016/s0002-9343(00)00682-3 View journal details

Analysis Services

Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs.

Contact

WeChat Official Account