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PMID: 11178119 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8.

Arthritis research ·Vol. 3 ·No. 2 ·2001-00-00 ·Pages 118-26

Hayashida K, Nanki T, Girschick H, Yavuz S, Ochi T, Lipsky PE

Abstract

Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.

MeSH Terms
Adjuvants, Immunologic/pharmacology Arthritis, Rheumatoid/metabolism,pathology Cell Line Cell Movement Cell-Free System Chemokine CCL2/biosynthesis,physiology Humans Interleukin-8/biosynthesis,physiology Monocytes/metabolism,pathology RNA, Messenger/biosynthesis Receptors, Chemokine/biosynthesis Stromal Cells/metabolism,pathology Synovial Membrane/metabolism,pathology Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Adjuvants, Immunologic Chemokine CCL2 Interleukin-8 RNA, Messenger Receptors, Chemokine Tumor Necrosis Factor-alpha
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hayashida K
University of Texas, Southwestern Medical Center, Dallas, Texas, USA. [email protected]
Nanki T
Girschick H
Yavuz S
Ochi T
Lipsky P E
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Article Info
Journal
Arthritis research
Abbr.
Arthritis Res
ISSN
1465-9905
DOI
10.1186/ar149
Email
[email protected]
Published
2001-00-00
Epub
2001-00-05
Pages
118-26
Language
English
Region
England
NLM ID
100913255
PMCID
PMC17828
Subset
IM
Grants
NIAMS NIH HHS · AR-39169 · United States
External Links
PubMed source DOI: 10.1186/ar149 PMC Full Text
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