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PMID: 1123915 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A freeze-fracture study of the junctions between glomerular epithelial cells in aminonucleoside nephrosis.

Laboratory investigation; a journal of technical methods and pathology ·Vol. 32 ·No. 3 ·1975-03-00 ·Pages 397-403

Ryan GB, Leventhal M, Karnovsky MJ

Abstract

In rats with aminonucleoside nephrosis, glomerular slit pores are mostly replaced by sites of close apposition between adjacent epithelial cell membranes. In replicas of freeze-fractured glomeruli, such junctions showed incomplete fibrils or grooves typical of "leaky" zonulae occludentes.

MeSH Terms

Animals Basement Membrane/ultrastructure Capillaries/ultrastructure Cell Membrane/ultrastructure Cytoplasm/ultrastructure Endothelium/ultrastructure Epithelial Cells Epithelium/ultrastructure Freeze Fracturing Intercellular Junctions/ultrastructure Kidney Glomerulus/ultrastructure Male Microscopy, Electron Nephrosis/chemically induced,complications,pathology Proteinuria/etiology Puromycin Rats

Chemicals

Puromycin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ryan G B

Leventhal M

Karnovsky M J

Article Info

Journal

Laboratory investigation; a journal of technical methods and pathology

Abbr.

Lab Invest

ISSN

0023-6837

Published

1975-03-00

Pages

397-403

Language

English

Region

United States

NLM ID

0376617

Subset

External Links

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A freeze-fracture study of the junctions between glomerular epithelial cells in aminonucleoside nephrosis.

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