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PMID: 11239480 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

How understanding the control of energy metabolism can help investigation of mitochondrial dysfunction, regulation and pharmacology.

Biochimica et biophysica acta ·Vol. 1504 ·No. 1 ·2001-03-01 ·Pages 1-11

Murphy MP

Abstract

Understanding the control of mitochondrial energy metabolism is central to knowing how mitochondria function within cells. Metabolic control analysis is the best approach available for studying the control of mitochondrial energy metabolism. Here I outline how metabolic control analysis has been used to help understand mitochondrial regulation, damage and pharmacology.

MeSH Terms
Adenosine Triphosphate/metabolism Animals Energy Metabolism/physiology Humans Intracellular Membranes/metabolism Mitochondria/drug effects,metabolism,physiology Models, Chemical Oxidative Phosphorylation
Chemicals
Adenosine Triphosphate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Murphy M P
Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand. [email protected]
Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/s0005-2728(00)00234-6
Email
[email protected]
Published
2001-03-01
Pages
1-11
Language
English
Region
Netherlands
NLM ID
0217513
Subset
IM
External Links
PubMed source DOI: 10.1016/s0005-2728(00)00234-6
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