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PMID: 11252746 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The establishment of Spemann's organizer and patterning of the vertebrate embryo.

Nature reviews. Genetics ·Vol. 1 ·No. 3 ·2000-12-00 ·Pages 171-81

De Robertis EM, Larraín J, Oelgeschläger M, Wessely O

Abstract

Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.

MeSH Terms
Amino Acid Sequence Animals Body Patterning Glycoproteins/chemistry,genetics Intercellular Signaling Peptides and Proteins Molecular Sequence Data Sequence Homology, Amino Acid Vertebrates/embryology
Chemicals
Glycoproteins Intercellular Signaling Peptides and Proteins chordin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
De Robertis E M
Howard Hughes Medical Institute, and Department of Biological Chemistry, University of California, Los Angeles, California 90095-1662, USA. [email protected]
Larraín J
Oelgeschläger M
Wessely O
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0056
DOI
10.1038/35042039
Email
[email protected]
Published
2000-12-00
Pages
171-81
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2291143
Subset
IM
Grants
NICHD NIH HHS · R37 HD021502 · United States
NICHD NIH HHS · R37 HD021502-14 · United States
External Links
PubMed source DOI: 10.1038/35042039 PMC Full Text View journal details
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