The many substrates and functions of ATM.

Nature reviews. Molecular cell biology ·Vol. 1 ·No. 3 ·2000-12-00 ·Pages 179-86

Kastan MB, Lim DS

Abstract

As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.

MeSH Terms

Amino Acid Sequence Animals Ataxia Telangiectasia/diagnosis,genetics Ataxia Telangiectasia Mutated Proteins Cell Cycle Cell Cycle Proteins DNA Damage DNA Repair DNA-Binding Proteins Humans Models, Biological Molecular Sequence Data Phenotype Protein Serine-Threonine Kinases/genetics,metabolism,physiology Sequence Homology, Amino Acid Tumor Suppressor Proteins

Chemicals

Cell Cycle Proteins DNA-Binding Proteins Tumor Suppressor Proteins ATM protein, human Ataxia Telangiectasia Mutated Proteins Protein Serine-Threonine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kastan M B

Department of Hematology-Oncology, Saint Jude Children's Research Hospital, D1034, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA. [email protected]

Lim D S

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35043058

[email protected]

Published

2000-12-00

Pages

179-86

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35043058 View journal details

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