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PMID: 11252955 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Filamins as integrators of cell mechanics and signalling.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 2 ·2001-02-00 ·Pages 138-45

Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

MeSH Terms

Cell Membrane/physiology Contractile Proteins/physiology Filamins Microfilament Proteins/physiology Signal Transduction/physiology

Chemicals

Contractile Proteins Filamins Microfilament Proteins

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Stossel T P

Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. [email protected]

Condeelis J

Cooley L

Hartwig J H

Noegel A

Schleicher M

Shapiro S S

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35052082

[email protected]

Published

2001-02-00

Pages

138-45

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35052082 View journal details

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Filamins as integrators of cell mechanics and signalling.

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