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PMID: 11252957 Published · ppublish English Research Support, Non-U.S. Gov't Review

Retroviral recombination: what drives the switch?

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 2 ·2001-00-00 ·Pages 151-5

Negroni M, Buc H

Abstract

The high rate of recombination in retroviruses is due to the frequent template switching that occurs during reverse transcription. Although the mechanism that leads to this switch is still a matter of debate, there is increasing evidence that specific RNA structures are involved. And the implications might go beyond retroviral genetic variability.

MeSH Terms
Recombination, Genetic Retroviridae/genetics Transcription, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Negroni M
Department of Molecular Biology, Institut Pasteur, 75724 Paris 15, France. [email protected]
Buc H
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
DOI
10.1038/35052098
Email
[email protected]
Published
2001-00-00
Pages
151-5
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/35052098 View journal details
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