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PMID: 1125484 Published · ppublish English Journal Article

Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.

British journal of pharmacology ·Vol. 53 ·No. 1 ·1975-01-00 ·Pages 121-5

Boullin DJ, Grahame-Smith DG, Grimes RP, Woods HF

Abstract

1 Blood platelets from normal human subjects were isolated and aggregated in vitro with adenosine diphosphate (ADP) or 5-hydroxytryptamine (5-HT). 2 The effects of chlorpromazine and 7 major metabolites upon 5-HT-induced aggregation were investigated. 3 All the phenothiazines inhibited 5-HT-induced aggregation when added to platelet rich plasma 3 min prior to 5-HT. 4 There were no qualitative differences in the inhibitory effects, but inhibitory potency varied over a wide range. The decreasing order of potency was monodesmethylchlorpromazine, chlorpromazine, 7-hydroxychlorpromazine, didesmethylchlorpromazine, 3,7 -dimethoxy-chlorpromazine, didesmethylchlorpromazine sulphoxide, chlorpromazine sulphoxide, chlorpromazine nitroxide.

MeSH Terms
Adenosine Diphosphate/pharmacology Adolescent Adult Chlorpromazine/analogs & derivatives,pharmacology Female Humans In Vitro Techniques Male Platelet Adhesiveness/drug effects Platelet Aggregation/drug effects Serotonin Antagonists
Chemicals
Serotonin Antagonists Adenosine Diphosphate Chlorpromazine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Boullin D J
Grahame-Smith D G
Grimes R P
Woods H F
References (19)
19 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1975.tb07338.x
Published
1975-01-00
Pages
121-5
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1666266
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1975.tb07338.x PMC Full Text View journal details
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