Sphaerophorus necrophorus: laboratory model for the evaluation of chemotherapeutic agents in mice.

The Cornell veterinarian ·Vol. 65 ·No. 2 ·1975-04-00 ·Pages 187-204

Maestrone G, Sadek S, Kubacki E, Mitrovic M

Abstract

Severe necro-purulent lesions were induced in mice following parenteral inoculation of Sphaerophorus necrophorus. Gross and histological changes observed in the lung, liver, and foot pad of infected mice were similar to those occurring naturally in cattle. The lesions could be prevented, cured or significantly reduced by the administration of chemotherapeutic agents such as sulfonamides, potentiated sulfonamide and antibiotics. The application of this novel laboratory model infection in the primary evaluation of potential antibacterial agents is discussed.

MeSH Terms

Animals Chlortetracycline/therapeutic use Foot Fusobacterium Infections/drug therapy,pathology Fusobacterium necrophorum/drug effects,growth & development Injections Injections, Subcutaneous Leucomycins/therapeutic use Liver/pathology Lung/pathology Male Mice Microbial Sensitivity Tests Necrosis Neomycin/therapeutic use Oxytetracycline/therapeutic use Penicillins/therapeutic use Pyrimidines/therapeutic use Skin/pathology Sulfadimethoxine/therapeutic use Sulfamethoxazole/therapeutic use Thorax

Chemicals

Leucomycins Penicillins Pyrimidines Sulfadimethoxine Neomycin Sulfamethoxazole Chlortetracycline Oxytetracycline

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Maestrone G

Sadek S

Kubacki E

Mitrovic M

Article Info

Journal

The Cornell veterinarian

Abbr.

Cornell Vet

ISSN

0010-8901

Published

1975-04-00

Pages

187-204

Language

English

Region

United States

NLM ID

0074245

Subset

External Links

PubMed source

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Sphaerophorus necrophorus: laboratory model for the evaluation of chemotherapeutic agents in mice.

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