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PMID: 1127382 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.

The Journal of experimental medicine ·Vol. 141 ·No. 6 ·1975-06-01 ·Pages 1365-75

Lennon VA, Lindstrom JM, Seybold ME

Abstract

Immunization of animals with acetylcholine receptor (AChR) protein from the electric organs of Electrophorus electricus and Torpedo californica induces an autoimmune response to the AChR of mammalian skeletal muscle. Rats and guinea pigs develop experimental autoimmune myasthenia gravis (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The indicence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to myasthenia gravis (MG) of man in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic rat muscle AChR in the serum of rats with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and mg.

MeSH Terms

Acetylcholine Animals Autoantibodies/analysis Autoimmune Diseases Body Weight Disease Models, Animal Electric Organ/immunology Electromyography Electrophorus Female Guinea Pigs Myasthenia Gravis/etiology,immunology,physiopathology Neostigmine/pharmacology Posture Rats Sensory Receptor Cells/immunology Snake Venoms/pharmacology

Chemicals

Autoantibodies Snake Venoms Neostigmine Acetylcholine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lennon V A

Lindstrom J M

Seybold M E

References (13)

13 references, click to expand

MULTIPLE ANTIBODY PRODUCTION IN MYASTHENIA GRAVIS.
Lancet. 1963 Aug 24;2(7304):373-5 PMID: 14044286
Changes in serum complement activity in patients with myasthenia gravis.
Proc Soc Exp Biol Med. 1960 Oct;105:177-84 PMID: 13727889
Studies on purified eel acetylcholine receptor and anti-acetylcholine receptor antibody.
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3334-8 PMID: 4128544
Immunopharmacological disease: a break in tolerance to receptor sites.
Lancet. 1971 Mar 27;1(7700):630-3 PMID: 4101235
Quantal components of end-plate potentials in the myasthenic syndrome.
Ann N Y Acad Sci. 1971 Sep 15;183:183-99 PMID: 4330759
Myasthenia gravis in the dog.
J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):431-7 PMID: 4248323
Gradually increasing doses of prednisone in myasthenia gravis. Reducing the hazards of treatment.
N Engl J Med. 1974 Jan 10;290(2):81-4 PMID: 4808454
Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors.
Science. 1973 Oct 19;182(4109):293-5 PMID: 4742736
Autoimmune response to acetylcholine receptor.
Science. 1973 May 25;180(4088):871-2 PMID: 4706680
Electrical testing in myasthenia gravis.
Ann N Y Acad Sci. 1971 Sep 15;183:287-302 PMID: 5287827
Isolation of the principal neurotoxins of two Naja naja subspecies.
Eur J Biochem. 1971 Jul 15;21(1):1-16 PMID: 5568672
Thymectomy in juvenile myasthenia gravis.
Arch Neurol. 1971 Nov;25(5):385-92 PMID: 5110884
Electrophysiological study of neuromuscular blocking action of cobra neurotoxin.
Br J Pharmacol Chemother. 1966 Nov;28(2):172-81 PMID: 5972624

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.141.6.1365

Published

1975-06-01

Pages

1365-75

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2189842

Subset

External Links

PubMed source DOI: 10.1084/jem.141.6.1365 PMC Full Text View journal details

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Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.

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