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PMID: 1127684 Published · ppublish English Journal Article

Sugar transport by renal plasma membrane vesicles. Characterization of the systems in the brush-border microvilli and basal-lateral plasma membranes.

The Journal of membrane biology ·Vol. 21 ·No. 3-4 ·1975-00-00 ·Pages 375-95

Kinne R, Murer H, Kinne-Saffran E, Thees M, Sachs G

Abstract

Uptake studies of D-and L-glucose were performed on vesicles derived from brush-border and basal-lateral membranes. The uptake of the sugars into the vesicles was osmotically sensitive and independent of glucose metabolism. In brush-border vesicles D-glucose but not L-glucose transport was Na-+-dependent, wn the presence of an initial Na+gradient. Basal-lateral membranes take up D-glucose faster than L-glucose, but the D-glucose uptake is significantly less sensitive to sodium removal and only moderately inhibited by phlorzin as compared to the prush-border fraction.

MeSH Terms
Animals Biological Transport/drug effects Cell Membrane/metabolism Chick Embryo Glucose/metabolism Kidney Cortex/metabolism Osmolar Concentration Phloretin/pharmacology Phlorhizin/pharmacology Rats Sodium/pharmacology Stereoisomerism Temperature
Chemicals
Sodium Phlorhizin Glucose Phloretin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kinne R
Murer H
Kinne-Saffran E
Thees M
Sachs G
References (23)
23 references, click to expand
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01941077
Published
1975-00-00
Pages
375-95
Language
English
Region
United States
NLM ID
0211301
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01941077 View journal details
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