Rac1 activity is required for the activation of hypoxia-inducible factor 1.

Animals Binding Sites Cell Hypoxia/physiology Cell Line Chromones/pharmacology DNA-Binding Proteins/genetics,metabolism Enzyme Inhibitors/pharmacology Flavonoids/pharmacology Gene Expression Regulation Genetic Vectors Genistein/pharmacology Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Imidazoles/pharmacology Mammals Morpholines/pharmacology Nuclear Proteins/genetics,metabolism Phosphatidylinositol 3-Kinases/metabolism Pyridines/pharmacology Recombinant Fusion Proteins/genetics Signal Transduction/physiology Transcription Factors/metabolism Transcription, Genetic Transcriptional Activation Tumor Cells, Cultured rac1 GTP-Binding Protein/metabolism

Chromones DNA-Binding Proteins Enzyme Inhibitors Flavonoids HIF1A protein, human Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Imidazoles Morpholines Nuclear Proteins Pyridines Recombinant Fusion Proteins Transcription Factors 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one Genistein Phosphatidylinositol 3-Kinases rac1 GTP-Binding Protein SB 203580 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one