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PMID: 11283723 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Tie receptors: new modulators of angiogenic and lymphangiogenic responses.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 4 ·2001-04-00 ·Pages 257-67

Jones N, Iljin K, Dumont DJ, Alitalo K

Abstract

Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the angiopoietins, are beginning to provide insight into how vessels make decisions such as whether to grow or regress--processes that are important not only during development but throughout an organism's life.

MeSH Terms
Aging/physiology Angiopoietin-1 Animals Cell Adhesion Molecules/metabolism Cell Movement Cell Survival Endothelium, Vascular/cytology,metabolism,pathology Growth Substances/physiology Hematopoiesis Humans Hypoxia/blood,physiopathology Membrane Glycoproteins/metabolism Neoplasm Proteins/metabolism Neovascularization, Pathologic Neovascularization, Physiologic Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases/metabolism Receptors, Cell Surface/metabolism Receptors, TIE Signal Transduction
Chemicals
Angiopoietin-1 Cell Adhesion Molecules Growth Substances MEN1 protein, human Membrane Glycoproteins Neoplasm Proteins Proto-Oncogene Proteins Receptors, Cell Surface Receptor Protein-Tyrosine Kinases Receptors, TIE
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jones N
Department of Medical Biophysics, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, S-227, Toronto, Ontario, Canada M4N 3M5.
Iljin K
Dumont D J
Alitalo K
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
DOI
10.1038/35067005
Published
2001-04-00
Pages
257-67
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/35067005 View journal details
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