Cbl: many adaptations to regulate protein tyrosine kinases.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 4 ·2001-04-00 ·Pages 294-307

Thien CB, Langdon WY

Abstract

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

MeSH Terms

Actins/metabolism Animals Caenorhabditis elegans Proteins Cytoskeleton/metabolism Down-Regulation Embryonic Induction Helminth Proteins/metabolism Humans Mice Mice, Knockout Models, Molecular Oncogene Protein v-cbl Protein Structure, Tertiary Protein-Tyrosine Kinases/antagonists & inhibitors,metabolism Proto-Oncogene Mas Proto-Oncogene Proteins/chemistry,deficiency,genetics,metabolism Proto-Oncogene Proteins c-cbl Receptor Protein-Tyrosine Kinases/antagonists & inhibitors,metabolism Retroviridae Proteins, Oncogenic/chemistry,deficiency,genetics,metabolism Signal Transduction T-Lymphocytes/physiology Ubiquitin-Protein Ligases Ubiquitins/metabolism

Chemicals

Actins Caenorhabditis elegans Proteins Helminth Proteins MAS1 protein, human Oncogene Protein v-cbl Proto-Oncogene Mas Proto-Oncogene Proteins Retroviridae Proteins, Oncogenic Sli-1 protein, C elegans Ubiquitins Proto-Oncogene Proteins c-cbl Ubiquitin-Protein Ligases Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases CBL protein, human Cbl protein, mouse

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Thien C B

Department of Pathology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.

Langdon W Y

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35067100

Published

2001-04-00

Pages

294-307

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35067100 View journal details

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