Home LiteratureArticle Details
PMID: 1129140 Published · ppublish English Journal Article

A model for chromatin sub-structure incorporating symmetry considerations of histone oligomers.

Nucleic acids research ·Vol. 2 ·No. 3 ·1975-03-00 ·Pages 405-21

Hyde JE, Walker IO

Abstract

Symmetry considerations of the kind of structures which can be generated when dimers of histones f2al-f3 and f2a2-f2b interact lead to the following conclusions: chromatin subunits based on closed-shell structures give rise to discrete, non-interacting nucleoprotein subunits with the histones arranged at random along the DNA chain; open structures based on infinite helices give rise to highly ordered, regular arrangements of dimers. A model is proposed in which helical polymers of f2al-f3 and f2b-f2a2 form a central core with the DNA helically arranged around it. The helical repeat contains 9.6 turns of B-form DNA and one molecule each of f2al, f2a2, f2b, f3 and f1. The pitch of the helix is 53Angstrom and the other diameter 130Angstrom. The protein molecular repeat is 106Angstrom.

MeSH Terms
Amino Acid Sequence Binding Sites Chromatin/ultrastructure DNA Histones Molecular Weight Neutrons Nucleic Acid Conformation Oligopeptides Protein Binding Protein Conformation Scattering, Radiation X-Rays
Chemicals
Chromatin Histones Oligopeptides DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hyde J E
Walker I O
References (31)
31 references, click to expand
  1. Conformations and interactions of histones and their role in chromosome structure.
    Ann N Y Acad Sci. 1973 Dec 31;222:266-89 PMID: 4522432
  2. A two-subunit histone complex from calf thymus.
    Biochem Biophys Res Commun. 1974 Jul 24;59(2):542-7 PMID: 4859197
  3. A new procedure for the isolation and fractionation of histones.
    FEBS Lett. 1971 May 20;14(5):333-337 PMID: 11945791
  4. On the structure of nucleohistone.
    J Mol Biol. 1971 Feb 14;55(3):325-36 PMID: 5102527
  5. The reactivity of the thiol groups of calf thymus deoxyribonucleohistone.
    Nucleic Acids Res. 1974 Feb;1(2):203-15 PMID: 4472380
  6. Covalent cross-linking of histones in chromatin.
    FEBS Lett. 1975 Feb 1;50(2):150-4 PMID: 1112409
  7. Histones: structure and function.
    Annu Rev Biochem. 1971;40:279-314 PMID: 4941236
  8. A study of calf thymus histone fraction F2(b) by gel filtration.
    Biochem J. 1970 Nov;120(1):61-6 PMID: 5533201
  9. Interactions of histone LAK (f2a2) with histones KAS (f2b) and GRK (f2a1).
    Biochemistry. 1974 May 7;13(10):2098-104 PMID: 4857060
  10. A model for particulate structure in chromatin.
    Nucleic Acids Res. 1974 Nov;1(11):1579-86 PMID: 10793713
  11. THE STRUCTURE OF NUCLEOHISTONES AND NUCLEOPROTAMINES.
    J Mol Biol. 1963 Aug;7:142-63 PMID: 14065304
  12. Isolation of a histone IIb1-IIb2 complex.
    Biochem Biophys Res Commun. 1973 Oct 15;54(4):1588-94 PMID: 4754727
  13. ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.
    J Mol Biol. 1965 May;12:88-118 PMID: 14343300
  14. Subunit structure of chromatin.
    Nature. 1974 Sep 20;251(5472):249-51 PMID: 4422492
  15. Electrometric and spectrophotometric titration of histone and deoxyribonucleohistone.
    J Mol Biol. 1965 Dec;14(2):381-98 PMID: 5880857
  16. The viscosity of nucleohistone in urea.
    Biochim Biophys Acta. 1968 Jun 26;160(2):224-8 PMID: 5658124
  17. A super-coil model for nucleohistone.
    J Mol Biol. 1972 Jul 14;68(1):115-24 PMID: 5050359
  18. A complex of histones IIb2 and IV.
    Biochemistry. 1973 Mar 13;12(6):1035-43 PMID: 4688858
  19. Reconstitution of nucleohistone from homologous and heterologous components.
    J Mol Biol. 1968 Dec 14;38(2):249-50 PMID: 5761398
  20. The modification of deoxyribonucleohistone by trypsin and chymotrypsin.
    Eur J Biochem. 1973 May 2;34(3):519-26 PMID: 4736702
  21. Chromatin structure; oligomers of the histones.
    Science. 1974 May 24;184(4139):865-8 PMID: 4825888
  22. Symmetry of protein oligomers formed by isologous association.
    J Mol Biol. 1966 Dec 28;22(2):405-9 PMID: 5972777
  23. Chromatin structure: a repeating unit of histones and DNA.
    Science. 1974 May 24;184(4139):868-71 PMID: 4825889
  24. A NOTE ON REVERSIBLE DISSOCIATION OF DEOXYRIBONUCLEOHISTONE.
    J Mol Biol. 1964 Jul;9:246-9 PMID: 14200387
  25. A histone cross-complexing pattern.
    Biochemistry. 1974 Nov 19;13(24):4992-7 PMID: 4474009
  26. The subunit structure of the eukaryotic chromosome.
    Nature. 1975 Jan 24;253(5489):245-9 PMID: 1167623
  27. Chromatin neutron and X-ray diffraction studies and high resolution melting of DNA-histone complexes.
    Biochimie. 1974;56(6-7):987-94 PMID: 4447805
  28. Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease.
    Biochem Biophys Res Commun. 1973 May 15;52(2):504-10 PMID: 4711166
  29. The structure of nucleohistone. Hydrodynamic behaviour at high ionic strength.
    Eur J Biochem. 1971 Sep 13;22(1):1-4 PMID: 5099212
  30. The effect of trypsin on nuclease-resistant chromatin fragments.
    J Biol Chem. 1974 Jan 10;249(1):152-6 PMID: 4855624
  31. Self assembly of histone F2a1.
    Proc Natl Acad Sci U S A. 1974 Nov;71(11):4625-9 PMID: 4531005
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/2.3.405
Published
1975-03-00
Pages
405-21
Language
English
Region
England
NLM ID
0411011
PMCID
PMC342846
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/2.3.405 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2