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PMID: 1130120 Published · ppublish English Journal Article

Permanent neonatal diabetes mellitus: a case report with plasma insulin studies.

Zeitschrift fur Kinderheilkunde ·Vol. 118 ·No. 4 ·1975-00-00 ·Pages 271-81

Dorchy H, Ooms H, Loeb H

Abstract

The 11th case of permanent neonatal diabetes mellitus appearing during the first month of life is reported. A critical review of the literature is also presented. The permanence of diabetes is demonstrated by the duration of insulin therapy still necessary after 30 months. Insulin-stimulation tests have been performed some for the first time in such a young diabetic. They have shown a nearly total failure in beta-cell response, only very high doses of glucagon provoking a moderate insulin secretion. The absence of acetonuria is discussed. It can perhaps be explained by the hyperglycemia which, by a mass effect, brings about cellular glucose penetration and this stops liberation of Nefa's from adipose tissue.

MeSH Terms
Blood Glucose/analysis Chronic Disease Diabetes Mellitus/blood,diagnosis Drug Tolerance Glucagon Glucose Tolerance Test Humans Hyperglycemia/diagnosis Infant, Newborn Infant, Newborn, Diseases/blood,diagnosis Insulin/blood Male Tolbutamide
Chemicals
Blood Glucose Insulin Glucagon Tolbutamide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dorchy H
Ooms H
Loeb H
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48 references, click to expand
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Article Info
Journal
Zeitschrift fur Kinderheilkunde
Abbr.
Z Kinderheilkd
ISSN
0044-2917
DOI
10.1007/BF00492333
Published
1975-00-00
Pages
271-81
Language
English
Region
Germany
NLM ID
7604363
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00492333
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