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PMID: 11306024 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of connexin 30 in the developing mouse cochlea.

Brain research ·Vol. 898 ·No. 2 ·2001-04-20 ·Pages 364-7

Xia A, Katori Y, Oshima T, Watanabe K, Kikuchi T, Ikeda K

Abstract

Mutations in the GJB6 gene encoding connexin 30 (Cx30) can cause dominant forms of nonsyndromic deafness. By studying immunohistochemical localization of Cx30 in the mouse cochlea at different ages from 0 to 30 days after birth, we found that the expression of Cx30 is nearly the same as that of Cx26. These findings suggest that as well as Cx26, Cx30 may also contribute to the generation and maturation of endocochlear potential.

MeSH Terms
Age Factors Animals Animals, Newborn/anatomy & histology,growth & development,metabolism Cochlea/cytology,growth & development,metabolism Connexin 30 Connexins/genetics,metabolism DNA, Complementary Deafness/etiology,metabolism,physiopathology Endolymph/metabolism Gap Junctions/metabolism Hearing/physiology Immunohistochemistry Membrane Potentials/physiology Mice Mice, Inbred CBA/anatomy & histology,growth & development,metabolism Perilymph/metabolism Potassium/metabolism Reverse Transcriptase Polymerase Chain Reaction
Chemicals
Connexin 30 Connexins DNA, Complementary Gjb6 protein, mouse Potassium
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Xia A
Department of Otorhinolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan. [email protected]
Katori Y
Oshima T
Watanabe K
Kikuchi T
Ikeda K
Article Info
Journal
Brain research
Abbr.
Brain Res
ISSN
0006-8993
DOI
10.1016/s0006-8993(01)02216-8
Email
[email protected]
Published
2001-04-20
Pages
364-7
Language
English
Region
Netherlands
NLM ID
0045503
Subset
IM
External Links
PubMed source DOI: 10.1016/s0006-8993(01)02216-8 View journal details
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