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PMID: 11322939 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mitochondrial permeability transition and oxidative stress.

FEBS letters ·Vol. 495 ·No. 1-2 ·2001-04-20 ·Pages 12-5

Kowaltowski AJ, Castilho RF, Vercesi AE

Abstract

Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.

MeSH Terms

Animals Antioxidants/metabolism,pharmacology Apoptosis Calcium/metabolism,pharmacology Humans Ion Channels Membrane Proteins/drug effects,physiology Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore NAD/metabolism Necrosis Oxidation-Reduction/drug effects Oxidative Stress/drug effects,physiology Phosphates/metabolism,pharmacology Reactive Oxygen Species/metabolism Sulfhydryl Compounds/antagonists & inhibitors,metabolism

Chemicals

Antioxidants Ion Channels Membrane Proteins Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Phosphates Reactive Oxygen Species Sulfhydryl Compounds NAD Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kowaltowski A J

Departamento de Bioquímica, Instituto de Quimica, Universidade de São Paulo, São Paulo, SP, Brazil.

Castilho R F

Vercesi A E

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/s0014-5793(01)02316-x

Published

2001-04-20

Pages

12-5

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/s0014-5793(01)02316-x View journal details

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