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PMID: 1132687 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chemotaxis-defective mutants of the nematode Caenorhabditis elegans.

Genetics ·Vol. 80 ·No. 2 ·1975-06-00 ·Pages 297-309

Dusenbery DB, Sheridan RE, Russell RL

Abstract

The technique of countercurrent separation has been used to isolate 17 independent chemotaxis-defective mutants of the nematode Caenorhabditis elegans. The mutants, selected to be relatively insensitive to the normally attractive salt NaCl, show varying degrees of residual sensitivity; some are actually weakly repelled by NaCl. The mutants are due to single gene defects, are autosomal and recessive, and identify at least five complementation groups.

MeSH Terms
Animals Breeding Chemotaxis Countercurrent Distribution Ethyl Methanesulfonate/pharmacology Female Genes, Recessive Genetics, Behavioral Male Mutagens Mutation Nematoda/physiology Nervous System Selection, Genetic Sodium Chloride
Chemicals
Mutagens Sodium Chloride Ethyl Methanesulfonate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dusenbery D B
Sheridan R E
Russell R L
References (5)
5 references, click to expand
  1. Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants.
    Proc Natl Acad Sci U S A. 1973 Mar;70(3):817-21 PMID: 4351805
  2. Structure and development of neuronal connections in isogenic organisms: variations and similarities in the optic system of Daphnia magna.
    Proc Natl Acad Sci U S A. 1973 Jan;70(1):57-61 PMID: 4509664
  3. Electron microscopical reconstruction of the anterior sensory anatomy of the nematode Caenorhabditis elegans.?2UU.
    J Comp Neurol. 1975 Apr 1;160(3):313-37 PMID: 1112927
  4. Genetic control of an insect neuronal network.
    Science. 1971 Dec 10;174(4014):1139-41 PMID: 5133732
  5. Genetic modification of electric properties in an excitable membrane (paramecium-calcium conductance-electrophysiological measurements-membrane mutant).
    Proc Natl Acad Sci U S A. 1972 Jan;69(1):93-7 PMID: 4500559
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
Published
1975-06-00
Pages
297-309
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1213328
Subset
IM
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