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PMID: 11335119 Published · ppublish English Journal Article

Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.

Mechanisms of development ·Vol. 103 ·No. 1-2 ·2001-05-00 ·Pages 127-31

Wagner K, Mincheva A, Korn B, Lichter P, Pöpperl H

Abstract

Members of the Pbx family are involved in a diverse range of developmental processes including axial patterning and organogenesis. Pbx functions are in part mediated by the interaction of Pbx proteins with members of the Hox and Meis/Prep families. We have identified a fourth mammalian Pbx family member. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.

MeSH Terms
Amino Acid Sequence Animals Blotting, Northern Chromosome Mapping Chromosomes, Human, Pair 19 DNA Primers DNA, Complementary/metabolism DNA-Binding Proteins/biosynthesis,genetics Humans Immunohistochemistry In Situ Hybridization In Situ Hybridization, Fluorescence Male Meiosis Mice Models, Genetic Molecular Sequence Data Protein Binding Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Spermatogenesis Testis/metabolism Tissue Distribution Transcription Factors
Chemicals
DNA Primers DNA, Complementary DNA-Binding Proteins PBX4 protein, human Pbx4 protein, mouse Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wagner K
Abteilung Pathogenitätsmechanismen, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Mincheva A
Korn B
Lichter P
Pöpperl H
Article Info
Journal
Mechanisms of development
Abbr.
Mech Dev
ISSN
0925-4773
Published
2001-05-00
Pages
127-31
Language
English
Region
Ireland
NLM ID
9101218
Subset
IM
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