Transposable plasmid deoxyribonucleic acid sequence in Pseudomonas aeruginosa which mediates resistance to gentamicin and four other antimicrobial agents.
A 9.1 x 10(6)-dalton transposable deoxyribonucleic acid sequence resides within Pseudomonas aeruginosa plasmid R1033 and mediates resistance to gentamicin, streptomycin, sulfamethoxazole, chloramphenicol, and mercuric chloride. Transposability was demonstrated in Escherichia coli when this sequence, designated Tn1696, excised from R1033 and integrated into plasmid pMB8. Excision and insertion of Tn1696 occurred independently of the host Rec phenotype and may involve the 140-base pair, inverted deoxyribonucleic acid repeated region that flanks this sequence. Occurrence of a multiresistance transposon on a transferrable plasmid that has a broad host range may have serious epidemiological and therapeutic consequences.
18 references, click to expand
-
A simple method for the preparation of large quantities of pure plasmid DNA.Biochim Biophys Acta. 1975 Apr 2;383(4):457-63 PMID: 1092355
-
Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria.Methods Enzymol. 1975;43:737-55 PMID: 1094240
-
Deletions affecting the transposition of an antibiotic resistance gene.Proc Natl Acad Sci U S A. 1977 Feb;74(2):702-6 PMID: 322140
-
The transposon Tn1 as a probe for studying ColE1 structure and function.Mol Gen Genet. 1977 Mar 7;151(2):151-60 PMID: 327263
-
Construction and characterization of new cloning vehicles. I. Ampicillin-resistant derivatives of the plasmid pMB9.Gene. 1977;2(2):75-93 PMID: 344136
-
Method for the genetic labeling of cryptic plasmids.J Bacteriol. 1978 Mar;133(3):1520-3 PMID: 346579
-
Common plasmid specifying tobramycin resistance found in two enteric bacteria isolated from burn patients.Antimicrob Agents Chemother. 1978 Feb;13(2):312-7 PMID: 348100
-
Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA.Proc Natl Acad Sci U S A. 1972 Aug;69(8):2110-4 PMID: 4559594
-
Pedigrees of some mutant strains of Escherichia coli K-12.Bacteriol Rev. 1972 Dec;36(4):525-57 PMID: 4568763
-
Isolation of an E. coli strain with a mutation affecting DNA polymerase.Nature. 1969 Dec 20;224(5225):1164-6 PMID: 4902142
-
Amikacin, an aminoglycoside with marked activity against antibiotic-resistant clinical isolates.J Infect Dis. 1976 Nov;134 SUPPL:S249-61 PMID: 62814
-
Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: independence from host rec functions and orientation of insertion.J Bacteriol. 1976 Oct;128(1):425-34 PMID: 789346
-
beta-Lactamases and resistance to penicillins and cephalosporins in Serratia marcescens.J Infect Dis. 1976 Sep;134(3):245-51 PMID: 789784
-
Further properties of P-2 R-factors of Pseudomonas aeruginosa and their relationship to other plasmid groups.Can J Microbiol. 1975 May;21(5):592-605 PMID: 804983
-
Third type of plasmid conferring gentamicin resistance in Pseudomonas aeruginosa.Antimicrob Agents Chemother. 1975 Sep;8(3):227-30 PMID: 810080
-
A molecular analysis of transductional marker rescue involving P-group plasmids in Pseudomonas aeruginosa.Mol Gen Genet. 1976 Feb 2;143(3):333-7 PMID: 814405
-
Recombination between plasmids of incompatibility groups P-1 and P-2.J Bacteriol. 1976 Sep;127(3):1278-85 PMID: 821925
-
Simple agarose gel electrophoretic method for the identification and characterization of plasmid deoxyribonucleic acid.J Bacteriol. 1976 Sep;127(3):1529-37 PMID: 821935
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
