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PMID: 11339 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Properties of the larval neuromuscular junction in Drosophila melanogaster.

The Journal of physiology ·Vol. 262 ·No. 1 ·1976-10-00 ·Pages 189-214

Jan LY, Jan YN

Abstract

The anatomy and physiology of the Drosophila larval neuromuscular junction were studied. 2. The dependence of muscle resting potentials on [K+]o and [Na+]o follows the Goldman-Hodgkin-Katz equation (PNa/PK=0-23). Chloride ions distribute passively across the membrane. 3. The mean specific membrane resistance of muscle fibres is 4-3 X 10(3) omega cm2, and the mean specific membrane capacitance is 7-1 muF/cm2. The muscle fibre is virtually isopotential. 4. Transmitter release is quantal. Both the miniature excitatory junctional potential and the evoked release follow the Poisson distribution. 5. Transmitter release depends on approximately the fourth power of [Ca2+]o. If Sr2+ replaces Ca2+, it depends on approximately the fourth power of [Sr2+]o. Mg2+ reduces transmitter release without altering the fourth power dependence on [Ca2+]o.

MeSH Terms
Animals Calcium/metabolism Chlorides/metabolism Drosophila melanogaster/physiology Hydrogen-Ion Concentration Larva Magnesium/pharmacology Membrane Potentials Neuromuscular Junction/physiology Osmolar Concentration Potassium/metabolism Sodium/metabolism Strontium/pharmacology Synaptic Transmission/drug effects
Chemicals
Chlorides Sodium Magnesium Potassium Calcium Strontium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jan L Y
Jan Y N
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31 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1976.sp011592
Published
1976-10-00
Pages
189-214
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1307637
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1976.sp011592 PMC Full Text View journal details
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