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PMID: 11344579 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Stimulation of heme oxygenase in macrophages and liver by endotoxin.

The Journal of clinical investigation ·Vol. 53 ·No. 2 ·1974-02-00 ·Pages 647-51

Gemsa D, Woo CH, Fudenberg HH, Schmid R

Abstract

In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by the ingested erythrocyte hemoglobin. Endotoxin neither appeared to injure the erythrocytes, nor did it enhance the rate of erythrophagocytosis. In intact rats, HO activity in both parenchymal and sinusoidal cells of the liver was increased after treatment with endotoxin. It is likely that endotoxin directly stimulates HO activity, a process which may account for the reported rise in bilirubin formation in endotoxin-treated animals. The effect of endotoxin on HO may represent part of the general activation of phagocytic cells by endotoxin.

MeSH Terms
Animals Erythrocytes/drug effects,immunology Female Heme Oxygenase (Decyclizing)/metabolism Lipopolysaccharides/administration & dosage,adverse effects,metabolism Liver/drug effects,enzymology Macrophages, Peritoneal/drug effects,enzymology Phagocytosis/immunology Rats Rats, Sprague-Dawley
Chemicals
Lipopolysaccharides Heme Oxygenase (Decyclizing)
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gemsa D
Department of Medicine, University of California, San Francisco, California 94143, USA.
Woo C H
Fudenberg H H
Schmid R
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24 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI107599
Published
1974-02-00
Pages
647-51
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC301508
Subset
IM
Grants
NIADDK NIH HHS · AM-05598 · United States
NIADDK NIH HHS · AM-11275 · United States
NICHD NIH HHS · HD-05894 · United States
NHLBI NIH HHS · HL-05677 · United States
External Links
PubMed source DOI: 10.1172/JCI107599 PMC Full Text View journal details
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