Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions.

British journal of cancer ·Vol. 84 ·No. 10 ·2001-05-18 ·Pages 1387-90

Colella G, Pennati M, Bearzatto A, Leone R, Colangelo D, Manzotti C, Daidone MG, Zaffaroni N

Abstract

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin. Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464. Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N- ras) level were observed between BBR 3464 and CDDP.

MeSH Terms

Adaptor Proteins, Signal Transducing Adenosine Triphosphatases Antineoplastic Agents/toxicity Base Pair Mismatch Carrier Proteins Cell Survival/drug effects Cisplatin/toxicity DNA Repair/drug effects,genetics DNA Repair Enzymes DNA-Binding Proteins Drug Resistance, Neoplasm Endonucleases Female Humans Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 Neoplasm Proteins/genetics Nuclear Proteins Organoplatinum Compounds/toxicity Ovarian Neoplasms Polymerase Chain Reaction Proteins/genetics Tumor Cells, Cultured

Chemicals

Adaptor Proteins, Signal Transducing Antineoplastic Agents Carrier Proteins DNA-Binding Proteins MLH1 protein, human Neoplasm Proteins Nuclear Proteins Organoplatinum Compounds Proteins ERCC1 protein, human Endonucleases Adenosine Triphosphatases PMS2 protein, human Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 DNA Repair Enzymes BBR 3464 Cisplatin

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Colella G

Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.

Pennati M

Bearzatto A

Leone R

Colangelo D

Manzotti C

Daidone M G

Zaffaroni N

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1054/bjoc.2001.1751

Published

2001-05-18

Pages

1387-90

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2363643

Subset

External Links

PubMed source DOI: 10.1054/bjoc.2001.1751 PMC Full Text View journal details

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Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions.

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