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PMID: 11383325 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

PPAR gamma: an essential role in metabolic control.

Nutrition, metabolism, and cardiovascular diseases : NMCD ·Vol. 11 ·No. 1 ·2001-02-00 ·Pages 64-9

Fajas L, Debril MB, Auwerx J

Abstract

The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.

MeSH Terms

Adipose Tissue/metabolism Animals Arteriosclerosis/etiology Gene Expression Humans Inflammation/etiology Insulin/physiology Ligands Prostaglandin D2/analogs & derivatives,analysis Receptors, Cytoplasmic and Nuclear/genetics,metabolism,physiology Thiazoles Thiazolidinediones Transcription Factors/genetics,metabolism,physiology

Chemicals

Insulin Ligands Receptors, Cytoplasmic and Nuclear Thiazoles Thiazolidinediones Transcription Factors 9-deoxy-delta-9-prostaglandin D2 2,4-thiazolidinedione Prostaglandin D2

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fajas L

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France.

Debril M B

Auwerx J

Article Info

Journal

Nutrition, metabolism, and cardiovascular diseases : NMCD

Abbr.

Nutr Metab Cardiovasc Dis

ISSN

0939-4753

Published

2001-02-00

Pages

64-9

Language

English

Region

Netherlands

NLM ID

9111474

Subset

External Links

PubMed source View journal details

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PPAR gamma: an essential role in metabolic control.

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