Home LiteratureArticle Details
PMID: 11401954 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Tuberculosis: latency and reactivation.

Infection and immunity ·Vol. 69 ·No. 7 ·2001-07-00 ·Pages 4195-201

Flynn JL, Chan J

Abstract

暂无摘要

MeSH Terms
Animals Disease Models, Animal Humans Tuberculosis/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Flynn J L
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. [email protected]
Chan J
References (77)
77 references, click to expand
  1. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group.
    Lancet. 1999 Dec 4;354(9194):1932-9 PMID: 10622295
  2. Dynamics of submerged growth of Mycobacterium tuberculosis under aerobic and microaerophilic conditions.
    Am Rev Respir Dis. 1976 Oct;114(4):807-11 PMID: 823851
  3. A mouse model of the recrudescence of latent tuberculosis in the elderly.
    Am Rev Respir Dis. 1988 Mar;137(3):716-8 PMID: 3345049
  4. Identification of nitric oxide synthase as a protective locus against tuberculosis.
    Proc Natl Acad Sci U S A. 1997 May 13;94(10):5243-8 PMID: 9144222
  5. Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS).
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11554-9 PMID: 10500215
  6. In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta.
    Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3926-31 PMID: 9108081
  7. Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-gamma and primed lymphocytes.
    J Immunol. 1998 May 1;160(9):4490-9 PMID: 9574555
  8. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
    Science. 1993 Mar 19;259(5102):1739-42 PMID: 8456300
  9. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.
    Immunity. 1995 Jun;2(6):561-72 PMID: 7540941
  10. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.
    Cell. 1995 May 19;81(4):641-50 PMID: 7538909
  11. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guérin involves class II transactivator and depends on the Nramp1 gene.
    J Immunol. 1999 Sep 1;163(5):2688-96 PMID: 10453010
  12. Immunology of tuberculosis.
    Annu Rev Immunol. 2001;19:93-129 PMID: 11244032
  13. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
    Nature. 1998 Jun 11;393(6685):537-44 PMID: 9634230
  14. Metronidazole therapy in mice infected with tuberculosis.
    Antimicrob Agents Chemother. 1999 May;43(5):1285-8 PMID: 10223954
  15. Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene.
    Science. 1998 Oct 23;282(5389):759-62 PMID: 9784137
  16. Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent.
    Infect Immun. 2000 Dec;68(12):6954-61 PMID: 11083819
  17. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
    Nature. 2000 Aug 17;406(6797):735-8 PMID: 10963599
  18. Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers.
    J Immunol. 1998 Nov 1;161(9):4882-93 PMID: 9794422
  19. Reactivation of latent tuberculosis: variations on the Cornell murine model.
    Infect Immun. 1999 Sep;67(9):4531-8 PMID: 10456896
  20. Analysis of rifapentine for preventive therapy in the Cornell mouse model of latent tuberculosis.
    Antimicrob Agents Chemother. 1999 Sep;43(9):2126-30 PMID: 10471552
  21. Metronidazole has no antibacterial effect in Cornell model murine tuberculosis.
    Int J Tuberc Lung Dis. 1998 Sep;2(9):736-42 PMID: 9755928
  22. Analysis of the host-parasite equilibrium in chronic murine tuberculosis by total and viable bacillary counts.
    Br J Exp Pathol. 1961 Feb;42:83-8 PMID: 13740304
  23. Immune responses in tuberculosis.
    Curr Opin Immunol. 2000 Aug;12(4):432-6 PMID: 10899019
  24. Lymphocyte subsets in granulomas of human tuberculosis: an in situ immunofluorescence study using monoclonal antibodies.
    Pathology. 1990 Jul;22(3):153-5 PMID: 2243727
  25. Presentation of mycobacterial antigens by human dendritic cells: lack of transfer from infected macrophages.
    Infect Immun. 1993 Dec;61(12):5326-32 PMID: 7693599
  26. Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice.
    Infect Immun. 1999 Aug;67(8):3980-8 PMID: 10417164
  27. Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2.
    J Exp Med. 2000 Aug 7;192(3):347-58 PMID: 10934223
  28. Synchronized replication of Mycobacterium tuberculosis.
    Infect Immun. 1977 Sep;17(3):528-30 PMID: 409675
  29. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis.
    Infect Immun. 1995 Feb;63(2):736-40 PMID: 7529749
  30. Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.
    Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11786-91 PMID: 8876215
  31. Effects of aminoguanidine on latent murine tuberculosis.
    J Immunol. 1998 Feb 15;160(4):1796-803 PMID: 9469439
  32. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology.
    Infect Immun. 2001 Mar;69(3):1847-55 PMID: 11179363
  33. Disseminated tuberculosis in interferon gamma gene-disrupted mice.
    J Exp Med. 1993 Dec 1;178(6):2243-7 PMID: 8245795
  34. Mycobacterium tuberculosis inhibits MHC class II antigen processing in murine bone marrow macrophages.
    Cell Immunol. 2000 Apr 10;201(1):63-74 PMID: 10805975
  35. Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.
    Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):8036-40 PMID: 7644534
  36. Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5).
    Scand J Immunol. 2000 Oct;52(4):369-79 PMID: 11013008
  37. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.
    J Exp Med. 1992 Apr 1;175(4):1111-22 PMID: 1552282
  38. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor.
    Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12844-8 PMID: 10536010
  39. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence.
    Infect Immun. 1996 Jun;64(6):2062-9 PMID: 8675308
  40. Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis.
    Mol Microbiol. 1999 Oct;34(2):257-67 PMID: 10564470
  41. Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 1994 Sep;38(9):2054-8 PMID: 7811018
  42. Therapy of tuberculosis in mice by DNA vaccination.
    Nature. 1999 Jul 15;400(6741):269-71 PMID: 10421369
  43. Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions.
    Infect Immun. 1982 Sep;37(3):1042-9 PMID: 6813266
  44. Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells.
    Eur J Immunol. 2000 Dec;30(12):3689-98 PMID: 11169412
  45. Recent advances in epidemiological research in tuberculosis.
    Adv Tuberc Res. 1980;20:1-63 PMID: 7395639
  46. Microbial persistence. II. Characteristics of the sterile state of tubercle bacilli.
    J Exp Med. 1966 Mar 1;123(3):469-86 PMID: 4957011
  47. Does the risk of tuberculosis increase in old age?
    J Infect Dis. 1983 May;147(5):951-5 PMID: 6842028
  48. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.
    J Immunol. 1999 Oct 1;163(7):3898-906 PMID: 10490990
  49. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
    Mol Cell. 2000 Apr;5(4):717-27 PMID: 10882107
  50. The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. II. The conversion of tuberculous infection to the latent state by the administration of pyrazinamide and a companion drug.
    J Exp Med. 1956 Nov 1;104(5):763-802 PMID: 13367342
  51. Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.
    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3193-8 PMID: 8622912
  52. Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice.
    Mol Microbiol. 2000 May;36(3):630-7 PMID: 10844652
  53. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.
    J Immunol. 1999 May 1;162(9):5407-16 PMID: 10228018
  54. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family.
    Science. 2000 May 26;288(5470):1436-9 PMID: 10827956
  55. Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria.
    Immunol Today. 1998 Nov;19(11):491-4 PMID: 9818540
  56. Sigma factors of Mycobacterium tuberculosis.
    Tuber Lung Dis. 1997;78(3-4):175-83 PMID: 9713650
  57. THE CHALLENGE OF TUBERCULOSIS IN DECLINE. A STUDY BASED ON THE EPIDEMIOLOGY OF TUBERCULOSIS IN ONTARIO, CANADA.
    Am Rev Respir Dis. 1964 Nov;90:707-20 PMID: 14211457
  58. Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-beta 1.
    J Infect Dis. 1994 Nov;170(5):1229-37 PMID: 7963718
  59. Effect of age on the enzymes of tricarboxylic acid and related cycles in Mycobacterium tuberculosis H37Rv.
    Am Rev Respir Dis. 1973 Sep;108(3):689-90 PMID: 4200820
  60. Exacerbation of acute and chronic murine tuberculosis by administration of a tumor necrosis factor receptor-expressing adenovirus.
    J Infect Dis. 1995 Feb;171(2):400-5 PMID: 7844377
  61. The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice.
    J Exp Med. 2001 Feb 5;193(3):271-80 PMID: 11157048
  62. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project.
    JAMA. 1999 Aug 18;282(7):677-86 PMID: 10517722
  63. Identification of viable and non-viable Mycobacterium tuberculosis in mouse organs by directed RT-PCR for antigen 85B mRNA.
    Microb Pathog. 2000 Jun;28(6):335-42 PMID: 10839970
  64. Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.
    Infect Immun. 2001 Mar;69(3):1722-8 PMID: 11179349
  65. Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis.
    J Bacteriol. 1999 Dec;181(23):7161-7 PMID: 10572116
  66. sigA is an essential gene in Mycobacterium smegmatis.
    Mol Microbiol. 1998 Jul;29(2):617-28 PMID: 9720877
  67. Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissues.
    J Exp Med. 1966 Mar 1;123(3):445-68 PMID: 4957010
  68. TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages.
    J Immunol. 1999 May 15;162(10):6122-31 PMID: 10229855
  69. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.
    J Immunol. 1999 Mar 15;162(6):3504-11 PMID: 10092807
  70. Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice.
    Nature. 1999 Nov 4;402(6757):79-83 PMID: 10573420
  71. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.
    Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12013-7 PMID: 1465432
  72. The Persistence of Tuberculous Infections.
    Am J Pathol. 1933;9(Suppl):711-718.1 PMID: 19970106
  73. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection.
    Cell. 1989 Mar 10;56(5):731-40 PMID: 2647299
  74. Genetic advances for studying Mycobacterium tuberculosis pathogenicity.
    Mol Microbiol. 1998 May;28(3):413-20 PMID: 9632247
  75. Fate of Mycobacterium tuberculosis within murine dendritic cells.
    Infect Immun. 2001 Feb;69(2):800-9 PMID: 11159971
  76. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
    J Exp Med. 1993 Dec 1;178(6):2249-54 PMID: 7504064
  77. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection.
    N Engl J Med. 1989 Mar 2;320(9):545-50 PMID: 2915665
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.69.7.4195-4201.2001
Email
[email protected]
Published
2001-07-00
Pages
4195-201
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC98451
Subset
IM
Grants
NIAID NIH HHS · AI36990 · United States
External Links
PubMed source DOI: 10.1128/IAI.69.7.4195-4201.2001 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2