Breaking the mitochondrial barrier.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 1 ·2001-01-00 ·Pages 63-7

Martinou JC, Green DR

Abstract

Pro- and anti-apoptotic members of the Bcl-2 family control the permeability of the outer mitochondrial membrane. They could do this either by forming autonomous pores in the membrane or by collaborating with components of the permeability transition pore. Here we discuss why we favour the first of these possibilities.

MeSH Terms

Animals Apoptosis/physiology Intracellular Membranes/physiology Mitochondria/physiology Models, Biological Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins c-bcl-2/physiology bcl-2-Associated X Protein

Chemicals

Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 bcl-2-Associated X Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Martinou J C

Departement de Biologie Cellulaire, Sciences III, 30 quai Ernest Ansermet, 1211 Genève 4, Switzerland. [email protected].

Green D R

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35048069

[email protected]

Published

2001-01-00

Pages

63-7

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35048069 View journal details

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Breaking the mitochondrial barrier.

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