ICOS costimulation: It's not just for TH2 cells anymore.

Nature immunology ·Vol. 2 ·No. 7 ·2001-07-00 ·Pages 573-4

Sperling AI, Bluestone JA

Abstract

A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.

MeSH Terms

Abatacept Animals Antigens, CD Antigens, Differentiation/immunology Antigens, Differentiation, T-Lymphocyte/immunology CD40 Ligand/immunology CTLA-4 Antigen Cytokines/immunology DNA-Binding Proteins/immunology GATA3 Transcription Factor Heart Transplantation/immunology Immunoconjugates Inducible T-Cell Co-Stimulator Protein Lymphocyte Activation/immunology Proto-Oncogene Proteins/immunology Proto-Oncogene Proteins c-maf Signal Transduction/immunology Th1 Cells/immunology Th2 Cells/immunology Trans-Activators/immunology Transplantation, Homologous/immunology

Chemicals

Antigens, CD Antigens, Differentiation Antigens, Differentiation, T-Lymphocyte CTLA-4 Antigen Cytokines DNA-Binding Proteins GATA3 Transcription Factor Immunoconjugates Inducible T-Cell Co-Stimulator Protein Proto-Oncogene Proteins Proto-Oncogene Proteins c-maf Trans-Activators CD40 Ligand Abatacept

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sperling A I

Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. [email protected]

Bluestone J A

Article Info

Journal

Nature immunology

Abbr.

Nat Immunol

ISSN

1529-2908

DOI

10.1038/89709

[email protected]

Published

2001-07-00

Pages

573-4

Language

English

Region

United States

NLM ID

100941354

Subset

Corrections

CommentOn

PMID: 11429542

CommentOn

PMID: 11429543

CommentOn

PMID: 11429544

External Links

PubMed source DOI: 10.1038/89709 View journal details

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ICOS costimulation: It's not just for TH2 cells anymore.

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