HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.

Adaptor Proteins, Signal Transducing Adenosine Triphosphatases Amino Acid Sequence Amino Acid Substitution Bacterial Proteins/chemistry,metabolism Base Pair Mismatch Carrier Proteins Colorectal Neoplasms, Hereditary Nonpolyposis/genetics DNA Repair DNA Repair Enzymes DNA Transposable Elements DNA-Binding Proteins Denmark Escherichia coli Escherichia coli Proteins Exodeoxyribonucleases/metabolism Humans Mismatch Repair Endonuclease PMS2 Molecular Sequence Data MutL Protein Homolog 1 MutL Proteins Mutation Mutation, Missense Neoplasm Proteins/chemistry,genetics,metabolism Nuclear Proteins Recombinant Fusion Proteins/chemistry,metabolism Sequence Alignment Sequence Homology, Amino Acid Whites

Adaptor Proteins, Signal Transducing Bacterial Proteins Carrier Proteins DNA Transposable Elements DNA-Binding Proteins Escherichia coli Proteins MLH1 protein, human MutL protein, E coli Neoplasm Proteins Nuclear Proteins Recombinant Fusion Proteins EXO1 protein, human Exodeoxyribonucleases exodeoxyribonuclease I Adenosine Triphosphatases PMS2 protein, human Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutL Proteins DNA Repair Enzymes