Translational control by CPEB: a means to the end.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 7 ·2001-07-00 ·Pages 521-9

Mendez R, Richter JD

Abstract

The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB--a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. What are the features and functions of this multifaceted protein?

MeSH Terms

Animals Cell Cycle/physiology Cytoplasm/metabolism Gene Expression Regulation Humans Models, Biological Molecular Structure Neuronal Plasticity Oocytes/physiology Phylogeny Protein Biosynthesis RNA, Messenger/metabolism RNA-Binding Proteins/chemistry,genetics,metabolism Transcription Factors/chemistry,genetics,metabolism Xenopus Proteins Xenopus laevis/embryology mRNA Cleavage and Polyadenylation Factors

Chemicals

CPEB1 protein, human Cpeb1 protein, Xenopus RNA, Messenger RNA-Binding Proteins Transcription Factors Xenopus Proteins mRNA Cleavage and Polyadenylation Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mendez R

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

Richter J D

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35080081

Published

2001-07-00

Pages

521-9

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35080081 View journal details

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