Biomedicine. Huntingtin--profit and loss.

Animals Apoptosis Brain-Derived Neurotrophic Factor/genetics,metabolism CREB-Binding Protein Caspases/metabolism Cells, Cultured Cerebral Cortex/metabolism,pathology Corpus Striatum/metabolism,pathology Gene Expression Regulation Humans Huntingtin Protein Huntington Disease/genetics,metabolism,pathology Mice Mice, Transgenic Mutation Nerve Tissue Proteins/chemistry,genetics,physiology Neurons/metabolism,pathology Nuclear Proteins/chemistry,genetics,metabolism,physiology Trans-Activators/metabolism Transcription Factors/metabolism Transcription, Genetic

Brain-Derived Neurotrophic Factor HTT protein, human Htt protein, mouse Huntingtin Protein Nerve Tissue Proteins Nuclear Proteins Trans-Activators Transcription Factors CREB-Binding Protein CREBBP protein, human Crebbp protein, mouse Caspases