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PMID: 11474709 Published · ppublish English Letter Research Support, Non-U.S. Gov't

In vitro activities of mitomycin C against growing and hypoxic dormant tubercle bacilli.

Antimicrobial agents and chemotherapy ·Vol. 45 ·No. 8 ·2001-08-00 ·Pages 2403-4

Peh HL, Toh A, Murugasu-Oei B, Dick T

Abstract

暂无摘要

MeSH Terms

Antibiotics, Antineoplastic/pharmacology Cell Survival/drug effects Colony Count, Microbial Humans Hypoxia/metabolism In Vitro Techniques Mitomycin/pharmacology Mycobacterium tuberculosis/drug effects,physiology

Chemicals

Antibiotics, Antineoplastic Mitomycin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Peh H L

Toh A

Murugasu-Oei B

Dick T

References (8)

8 references, click to expand

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis.
Nature. 2000 Jun 22;405(6789):962-6 PMID: 10879539
Latent Mycobacterium tuberculosis-persistence, patience, and winning by waiting.
Nat Med. 2000 Dec;6(12):1327-9 PMID: 11100115
Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG.
J Antimicrob Chemother. 2000 Dec;46(6):917-9 PMID: 11102410
Dormant tubercle bacilli: the key to more effective TB chemotherapy?
J Antimicrob Chemother. 2001 Jan;47(1):117-8 PMID: 11152444
Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 1994 Sep;38(9):2054-8 PMID: 7811018
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence.
Infect Immun. 1996 Jun;64(6):2062-9 PMID: 8675308
The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity.
Pharmacol Ther. 1997 Oct-Dec;76(1-3):73-87 PMID: 9535170
Oxygen depletion-induced dormancy in Mycobacterium bovis BCG.
J Bacteriol. 1999 Apr;181(7):2252-6 PMID: 10094705

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.45.8.2403-2404.2001

Published

2001-08-00

Pages

2403-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC90667

Subset

External Links

PubMed source DOI: 10.1128/AAC.45.8.2403-2404.2001 PMC Full Text View journal details

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In vitro activities of mitomycin C against growing and hypoxic dormant tubercle bacilli.

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