Interactions of carbenicillin and ticarcillin with gentamicin.

Antimicrobial agents and chemotherapy ·Vol. 7 ·No. 4 ·1975-04-00 ·Pages 431-4

Davies M, Morgan JR, Anand C

Abstract

The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.

MeSH Terms

Carbenicillin/pharmacology Dialysis Drug Interactions Gentamicins/antagonists & inhibitors,pharmacology Half-Life Humans Penicillins/pharmacology Ticarcillin/pharmacology

Chemicals

Gentamicins Penicillins Ticarcillin Carbenicillin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Davies M

Morgan J R

Anand C

References (9)

9 references, click to expand

Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin.
Lancet. 1971 Feb 6;1(7693):261-4 PMID: 4100015
Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea.
Lancet. 1967 Jun 17;1(7503):1289-93 PMID: 4165399
Use of gentamicin in combinations with other antibiotics.
J Infect Dis. 1969 Apr-May;119(4):370-7 PMID: 4306973
Administration of carbenicillin and ticarcillin--pharmaceutical aspects.
Eur J Cancer. 1973 Jun;9(6):425-33 PMID: 4214701
Laboratory and clinical conditions for gentamicin inactivation by carbenicillin.
Arch Intern Med. 1972 Dec;130(6):887-91 PMID: 5082469
Combined action of carbenicillin and gentamicin on Pseudomonas aeruginosa in vitro.
Appl Microbiol. 1969 Jun;17(6):893-6 PMID: 4978927
Simplified, accurate method for antibiotic assay of clinical specimens.
Appl Microbiol. 1966 Mar;14(2):170-7 PMID: 4959982
Synergy of carbenicillin and gentamicin in experimental infection with Pseudomonas.
J Infect Dis. 1971 Dec;124 Suppl:S46-55 PMID: 5164949
Combined use of gentamicin and carbenicillin.
Ann Intern Med. 1971 Dec;75(6):925-7 PMID: 5134902

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.7.4.431

Published

1975-04-00

Pages

431-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429157

Subset

External Links

PubMed source DOI: 10.1128/AAC.7.4.431 PMC Full Text View journal details

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Interactions of carbenicillin and ticarcillin with gentamicin.

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