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PMID: 1147900 Published · ppublish English Journal Article

Aerobic lactate production by mammary tissue.

The Biochemical journal ·Vol. 146 ·No. 1 ·1975-01-00 ·Pages 273-5

Elkin AR, Kuhn NJ

Abstract

Glucose uptake and L-lactate production were measured in cell, slice and intact tissue preparations of mammary glands from late-pregnant and lactating rats. The tissues showed extensive conversion of glucose into lactate in vitro, but not in vivo. Therefore aerobic lactate formation is not a normal feature of mammary tissue, but occurs in vitro as the result of some metabolic derangement.

MeSH Terms
Aerobiosis Animals Female Glucose/metabolism In Vitro Techniques Lactates/biosynthesis Lactation Mammary Glands, Animal/metabolism Pregnancy Rats
Chemicals
Lactates Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Elkin A R
Kuhn N J
References (12)
12 references, click to expand
  1. The Pasteur effect and the relations between respiration and fermentation.
    Essays Biochem. 1972;8:1-34 PMID: 4265190
  2. Characteristics of cells dissociated from mouse mammary glands. I. Method of separation and morphology of parenchymal cells from lactating glands.
    Exp Cell Res. 1969 Sep;57(1):43-62 PMID: 4309751
  3. Properties of pyruvate dehydrogenase of rat mammary tissue and its changes during pregnancy, lactation and weaning.
    Biochem J. 1974 Jul;142(1):87-95 PMID: 4374188
  4. Pentose cycle and reducing equivalents in rat mammary-gland slices.
    Biochem J. 1972 Jul;128(4):879-99 PMID: 4404768
  5. Measurements of substrate uptake by mammary gland of the rat.
    Biochem J. 1972 Oct;129(5):1171-3 PMID: 4676363
  6. Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo.
    Biochem J. 1973 Aug;134(4):1067-81 PMID: 4762752
  7. Cardiovascular changes during lactation in the rat.
    J Endocrinol. 1969 Jun;44(2):247-54 PMID: 5815831
  8. Effects of insulin on glucose metabolism by explants of mouse mammary gland maintained in organ culture.
    Biochim Biophys Acta. 1966 Aug 24;124(2):280-8 PMID: 5968900
  9. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
    Biochem J. 1956 Feb;62(2):315-23 PMID: 13293190
  10. RAT MAMMARY GLAND METABOLISM RELATIVE TO EPITHELIAL AND CONNECTIVE TISSUE CONTENT.
    Am J Physiol. 1964 Sep;207:595-600 PMID: 14220029
  11. The intermediary metabolism of the mammary gland; respiration and acid production of mammary tissue during pregnancy, lactation and involution in the rat.
    Biochem J. 1949;45(3):270-5 PMID: 15392850
  12. Lactogenesis in the rat. Changes in metabolic parameters at parturition.
    Biochem J. 1967 Dec;105(3):995-1002 PMID: 16742576
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Published
1975-01-00
Pages
273-5
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1165297
Subset
IM
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