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PMID: 11517311 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular phylogenetic analyses of the mitochondrial ADP-ATP carriers: the Plantae/Fungi/Metazoa trichotomy revisited.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 18 ·2001-08-28 ·Pages 10202-7

Löytynoja A, Milinkovitch MC

Abstract

We investigated the basal phylogeny of eukaryotes through analyses of sequences from the ADP-ATP mitochondrial carrier, a transmembrane protein that is stable in function across eukaryote kingdoms. The ADP-ATP data strongly suggest the grouping of Plantae and Fungi to the exclusion of Metazoa. We implemented several procedures to avoid pervasive analytical artifacts such as erroneous alignment, random rooting, long branch attraction, and misidentification of noisy characters. The quest of an eukaryote tree that would be largely consistent across multiple loci might be essentially illusory because of differential lineage sorting, horizontal gene transfer, and the chimeric nature of early eukaryotes. Better understanding of these evolutionary parameters, requiring separate phylogenetic analyses of multiple independent loci, is fundamental for resolution of the modes of emergence and evolution of the major eukaryote lineages.

MeSH Terms
Animals Eukaryotic Cells Evolution, Molecular Fungi/genetics,metabolism Mitochondria/genetics Mitochondrial ADP, ATP Translocases/genetics Phylogeny Plants/genetics,metabolism
Chemicals
Mitochondrial ADP, ATP Translocases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Löytynoja A
Unit of Evolutionary Genetics, Free University of Brussels (ULB), C.P. 300, Institute of Molecular Biology and Medicine, Rue Jeener and Brachet 12, B-6041 Gosselies, Belgium.
Milinkovitch M C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.181187698
Published
2001-08-28
Epub
2001-00-21
Pages
10202-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC56939
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.181187698 PMC Full Text View journal details
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