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PMID: 11562351 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Requirement of the JIP1 scaffold protein for stress-induced JNK activation.

Genes & development ·Vol. 15 ·No. 18 ·2001-09-15 ·Pages 2421-32

Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ

Abstract

The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.

MeSH Terms
Adaptor Proteins, Signal Transducing Animals Apoptosis Carrier Proteins/genetics,metabolism,physiology Enzyme Activation/physiology JNK Mitogen-Activated Protein Kinases Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinases/metabolism Neurons/enzymology,metabolism Oxidative Stress
Chemicals
Adaptor Proteins, Signal Transducing Carrier Proteins Mapk8ip protein, mouse JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Whitmarsh A J
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Kuan C Y
Kennedy N J
Kelkar N
Haydar T F
Mordes J P
Appel M
Rossini A A
Jones S N
Flavell R A
Rakic P
Davis R J
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.922801
Published
2001-09-15
Pages
2421-32
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC312784
Subset
IM
Grants
NCI NIH HHS · R01 CA085422 · United States
NCI NIH HHS · R01 CA065861 · United States
NIDDK NIH HHS · P30 DK032520 · United States
NIDDK NIH HHS · DK32520 · United States
NCI NIH HHS · CA65861 · United States
NCI NIH HHS · CA85422 · United States
External Links
PubMed source DOI: 10.1101/gad.922801 PMC Full Text View journal details
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