Integrating stress-response and cell-cycle checkpoint pathways.

Trends in cell biology ·Vol. 11 ·No. 10 ·2001-10-00 ·Pages 426-33

Pearce AK, Humphrey TC

Abstract

The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.

MeSH Terms

Animals Apoptosis/physiology Cell Cycle/physiology Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA Replication/physiology MAP Kinase Signaling System Models, Biological Oxidative Stress/physiology Phosphorylation Protein Kinases/metabolism,physiology Protein Serine-Threonine Kinases/genetics,metabolism Signal Transduction Transcription, Genetic Yeasts

Chemicals

Protein Kinases Checkpoint Kinase 2 Checkpoint Kinase 1 Protein Serine-Threonine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Pearce A K

Cell Cycle Laboratory, MRC Radiation and Genome Stability Unit, Harwell, OX11 0RD, Didcot, UK.

Humphrey T C

Article Info

Journal

Trends in cell biology

Abbr.

Trends Cell Biol

ISSN

0962-8924

DOI

10.1016/s0962-8924(01)02119-5

Published

2001-10-00

Pages

426-33

Language

English

Region

England

NLM ID

9200566

Subset

External Links

PubMed source DOI: 10.1016/s0962-8924(01)02119-5 View journal details

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